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首页> Proceedings of the National Academy of Sciences of the United States of America> Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.

Kallikrein directly interacts with and activates Factor IX, resulting in thrombin generation and fibrin formation independent of Factor XI.

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作者： Katherine J,Kearney ^[1] ; Juliet,Butler ^[1] ; Olga M,Posada ^[1] ; Clare,Wilson ^[1] ; Samantha,Heal ^[1] ; Majid,Ali ^[1] ; Lewis,Hardy ^[1] ; Josefin,Ahnström ^[2] ; David,Gailani ^[3] ; Richard,Foster ^[4] ; Emma,Hethershaw ^[1] ; Colin,Longstaff ^[5] ; Helen,Philippou ^[6]

作者单位： Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, LS2 9JT Leeds, United Kingdom. ^[1] Faculty of Medicine, Department of Immunology and Inflammation, Imperial College London, Hammersmith Campus, W12 0NN London, United Kingdom. ^[2] Division of Hematology/Oncology, The Vanderbilt Clinic, Vanderbilt University, Nashville, TN 37232. ^[3] School of Chemistry, University of Leeds, LS2 9JT Leeds, United Kingdom. ^[4] Division of Biotherapeutics, National Institute for Biological Standards and Control, Potters Bar, Hertfordshire, EN6 3QG, United Kingdom. ^[5] Leeds Institute of Cardiovascular and Metabolic Medicine, University of Leeds, LS2 9JT Leeds, United Kingdom; h.philippou@leeds.ac.uk. ^[6]

关键词 Factor IX Factor XII intrinsic pathway plasma kallikrein prekallikrein

主题词血液凝固(Blood Coagulation);缓激肽(Bradykinin);钙(Calcium);阳离子, 二价(Cations, Divalent);因子Ⅸ(Factor IX);因子Ⅺ(Factor XI);因子Ⅻ(Factor XII);纤维蛋白(Fibrin);人类(Humans);激肽释放酶类(Kallikreins);动力学(Kinetics);磷脂酰胆碱类(Phosphatidylcholines);磷脂酰乙醇胺类(Phosphatidylethanolamines);磷脂酰丝氨酸类(Phosphatidylserines);蛋白质结合(Protein Binding);凝血酶(Thrombin)

DOI 10.1073/pnas.2014810118

PMID 33397811

发布时间 2022-10-05

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Proceedings of the National Academy of Sciences of the United States of America

Proceedings of the National Academy of Sciences of the United States of America

2021年118卷3期

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Proceedings of the National Academy of Sciences of the United States of America

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Proceedings of the National Academy of Sciences of the United States of America

2021年118卷3期

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