第一作者:
                
                        
Vasiliki,Lagou
                        
                
            
            
                第一单位:
                
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.;VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
                            
                        
                
            
                    
                作者:
                
                        
Vasiliki,Lagou                                    [1]
                                    ;
                        
                        
Reedik,Mägi                                    [2]
                                    ;
                        
                        
Jouke- Jan,Hottenga                                    [3]
                                    ;
                        
                        
Harald,Grallert                                    [4]
                                    ;
                        
                        
John R B,Perry                                    [5]
                                    ;
                        
                        
Nabila,Bouatia-Naji                                    [6]
                                    ;
                        
                        
Letizia,Marullo                                    [7]
                                    ;
                        
                        
Denis,Rybin                                    [8]
                                    ;
                        
                        
Rick,Jansen                                    [9]
                                    ;
                        
                        
Josine L,Min                                    [10]
                                    ;
                        
                        
Antigone S,Dimas                                    [11]
                                    ;
                        
                        
Anna,Ulrich                                    [12]
                                    ;
                        
                        
Liudmila,Zudina                                    [12]
                                    ;
                        
                        
Jesper R,Gådin                                    [13]
                                    ;
                        
                        
Longda,Jiang                                    [14]
                                    ;
                        
                        
Alessia,Faggian                                    [12]
                                    ;
                        
                        
Amélie,Bonnefond                                    [15]
                                    ;
                        
                        
Joao,Fadista                                    [16]
                                    ;
                        
                        
Maria G,Stathopoulou                                    [17]
                                    ;
                        
                        
Aaron,Isaacs                                    [18]
                                    ;
                        
                        
Sara M,Willems                                    [19]
                                    ;
                        
                        
Pau,Navarro                                    [20]
                                    ;
                        
                        
Toshiko,Tanaka                                    [21]
                                    ;
                        
                        
Anne U,Jackson                                    [22]
                                    ;
                        
                        
May E,Montasser                                    [23]
                                    ;
                        
                        
Jeff R,O'Connell                                    [23]
                                    ;
                        
                        
Lawrence F,Bielak                                    [24]
                                    ;
                        
                        
Rebecca J,Webster                                    [25]
                                    ;
                        
                        
Richa,Saxena                                    [26]
                                    ;
                        
                        
Jeanette M,Stafford                                    [27]
                                    ;
                        
                        
Beate St,Pourcain                                    [10]
                                    ;
                        
                        
Nicholas J,Timpson                                    [10]
                                    ;
                        
                        
Perttu,Salo                                    [28]
                                    ;
                        
                        
So-Youn,Shin                                    [29]
                                    ;
                        
                        
Najaf,Amin                                    [30]
                                    ;
                        
                        
Albert V,Smith                                    [31]
                                    ;
                        
                        
Guo,Li                                    [32]
                                    ;
                        
                        
Niek,Verweij                                    [33]
                                    ;
                        
                        
Anuj,Goel                                    [34]
                                    ;
                        
                        
Ian,Ford                                    [35]
                                    ;
                        
                        
Paul C D,Johnson                                    [36]
                                    ;
                        
                        
Toby,Johnson                                    [37]
                                    ;
                        
                        
Karen,Kapur                                    [38]
                                    ;
                        
                        
Gudmar,Thorleifsson                                    [39]
                                    ;
                        
                        
Rona J,Strawbridge                                    [40]
                                    ;
                        
                        
Laura J,Rasmussen-Torvik                                    [41]
                                    ;
                        
                        
Tõnu,Esko                                    [2]
                                    ;
                        
                        
Evelin,Mihailov                                    [2]
                                    ;
                        
                        
Tove,Fall                                    [42]
                                    ;
                        
                        
Ross M,Fraser                                    [43]
                                    ;
                        
                        
Anubha,Mahajan                                    [44]
                                    ;
                        
                        
Stavroula,Kanoni                                    [45]
                                    ;
                        
                        
Vilmantas,Giedraitis                                    [46]
                                    ;
                        
                        
Marcus E,Kleber                                    [47]
                                    ;
                        
                        
Günther,Silbernagel                                    [48]
                                    ;
                        
                        
Julia,Meyer                                    [49]
                                    ;
                        
                        
Martina,Müller-Nurasyid                                    [50]
                                    ;
                        
                        
Andrea,Ganna                                    [51]
                                    ;
                        
                        
Antti-Pekka,Sarin                                    [52]
                                    ;
                        
                        
Loic,Yengo                                    [53]
                                    ;
                        
                        
Dmitry,Shungin                                    [54]
                                    ;
                        
                        
Jian'an,Luan                                    [5]
                                    ;
                        
                        
Momoko,Horikoshi                                    [55]
                                    ;
                        
                        
Ping,An                                    [56]
                                    ;
                        
                        
Serena,Sanna                                    [57]
                                    ;
                        
                        
Yvonne,Boettcher                                    [58]
                                    ;
                        
                        
N William,Rayner                                    [59]
                                    ;
                        
                        
Ilja M,Nolte                                    [60]
                                    ;
                        
                        
Tatijana,Zemunik                                    [61]
                                    ;
                        
                        
Erik van,Iperen                                    [62]
                                    ;
                        
                        
Peter,Kovacs                                    [63]
                                    ;
                        
                        
Nicholas D,Hastie                                    [20]
                                    ;
                        
                        
Sarah H,Wild                                    [64]
                                    ;
                        
                        
Stela,McLachlan                                    [64]
                                    ;
                        
                        
Susan,Campbell                                    [20]
                                    ;
                        
                        
Ozren,Polasek                                    [61]
                                    ;
                        
                        
Olga,Carlson                                    [65]
                                    ;
                        
                        
Josephine,Egan                                    [65]
                                    ;
                        
                        
Wieland,Kiess                                    [66]
                                    ;
                        
                        
Gonneke,Willemsen                                    [67]
                                    ;
                        
                        
Johanna,Kuusisto                                    [68]
                                    ;
                        
                        
Markku,Laakso                                    [68]
                                    ;
                        
                        
Maria,Dimitriou                                    [69]
                                    ;
                        
                        
Andrew A,Hicks                                    [70]
                                    ;
                        
                        
Rainer,Rauramaa                                    [71]
                                    ;
                        
                        
Stefania,Bandinelli                                    [72]
                                    ;
                        
                        
Barbara,Thorand                                    [73]
                                    ;
                        
                        
Yongmei,Liu                                    [74]
                                    ;
                        
                        
Iva,Miljkovic                                    [75]
                                    ;
                        
                        
Lars,Lind                                    [76]
                                    ;
                        
                        
Alex,Doney                                    [77]
                                    ;
                        
                        
Markus,Perola                                    [78]
                                    ;
                        
                        
Aroon,Hingorani                                    [79]
                                    ;
                        
                        
Mika,Kivimaki                                    [79]
                                    ;
                        
                        
Meena,Kumari                                    [80]
                                    ;
                        
                        
Amanda J,Bennett                                    [81]
                                    ;
                        
                        
Christopher J,Groves                                    [81]
                                    ;
                        
                        
Christian,Herder                                    [82]
                                    ;
                        
                        
Heikki A,Koistinen                                    [83]
                                    ;
                        
                        
Leena,Kinnunen                                    [84]
                                    ;
                        
                        
Ulf de,Faire                                    [85]
                                    ;
                        
                        
Stephan J L,Bakker                                    [86]
                                    ;
                        
                        
Matti,Uusitupa                                    [87]
                                    ;
                        
                        
Colin N A,Palmer                                    [77]
                                    ;
                        
                        
J Wouter,Jukema                                    [88]
                                    ;
                        
                        
Naveed,Sattar                                    [89]
                                    ;
                        
                        
Anneli,Pouta                                    [90]
                                    ;
                        
                        
Harold,Snieder                                    [60]
                                    ;
                        
                        
Eric,Boerwinkle                                    [91]
                                    ;
                        
                        
James S,Pankow                                    [92]
                                    ;
                        
                        
Patrik K,Magnusson                                    [93]
                                    ;
                        
                        
Ulrika,Krus                                    [94]
                                    ;
                        
                        
Chiara,Scapoli                                    [7]
                                    ;
                        
                        
Eco J C N,de Geus                                    [3]
                                    ;
                        
                        
Matthias,Blüher                                    [95]
                                    ;
                        
                        
Bruce H R,Wolffenbuttel                                    [96]
                                    ;
                        
                        
Michael A,Province                                    [56]
                                    ;
                        
                        
Goncalo R,Abecasis                                    [22]
                                    ;
                        
                        
James B,Meigs                                    [97]
                                    ;
                        
                        
G Kees,Hovingh                                    [98]
                                    ;
                        
                        
Jaana,Lindström                                    [99]
                                    ;
                        
                        
James F,Wilson                                    [100]
                                    ;
                        
                        
Alan F,Wright                                    [20]
                                    ;
                        
                        
George V,Dedoussis                                    [69]
                                    ;
                        
                        
Stefan R,Bornstein                                    [101]
                                    ;
                        
                        
Peter E H,Schwarz                                    [102]
                                    ;
                        
                        
Anke,Tönjes                                    [58]
                                    ;
                        
                        
Bernhard R,Winkelmann                                    [103]
                                    ;
                        
                        
Bernhard O,Boehm                                    [104]
                                    ;
                        
                        
Winfried,März                                    [105]
                                    ;
                        
                        
Andres,Metspalu                                    [2]
                                    ;
                        
                        
Jackie F,Price                                    [64]
                                    ;
                        
                        
Panos,Deloukas                                    [106]
                                    ;
                        
                        
Antje,Körner                                    [107]
                                    ;
                        
                        
Timo A,Lakka                                    [108]
                                    ;
                        
                        
Sirkka M,Keinanen-Kiukaanniemi                                    [109]
                                    ;
                        
                        
Timo E,Saaristo                                    [110]
                                    ;
                        
                        
Richard N,Bergman                                    [111]
                                    ;
                        
                        
Jaakko,Tuomilehto                                    [112]
                                    ;
                        
                        
Nicholas J,Wareham                                    [5]
                                    ;
                        
                        
Claudia,Langenberg                                    [5]
                                    ;
                        
                        
Satu,Männistö                                    [84]
                                    ;
                        
                        
Paul W,Franks                                    [113]
                                    ;
                        
                        
Caroline,Hayward                                    [20]
                                    ;
                        
                        
Veronique,Vitart                                    [20]
                                    ;
                        
                        
Jaakko,Kaprio                                    [114]
                                    ;
                        
                        
Sophie,Visvikis-Siest                                    [17]
                                    ;
                        
                        
Beverley,Balkau                                    [115]
                                    ;
                        
                        
David,Altshuler                                    [116]
                                    ;
                        
                        
Igor,Rudan                                    [64]
                                    ;
                        
                        
Michael,Stumvoll                                    [58]
                                    ;
                        
                        
Harry,Campbell                                    [64]
                                    ;
                        
                        
Cornelia M,van Duijn                                    [117]
                                    ;
                        
                        
Christian,Gieger                                    [118]
                                    ;
                        
                        
Thomas,Illig                                    [119]
                                    ;
                        
                        
Luigi,Ferrucci                                    [120]
                                    ;
                        
                        
Nancy L,Pedersen                                    [93]
                                    ;
                        
                        
Peter P,Pramstaller                                    [121]
                                    ;
                        
                        
Michael,Boehnke                                    [22]
                                    ;
                        
                        
Timothy M,Frayling                                    [122]
                                    ;
                        
                        
Alan R,Shuldiner                                    [123]
                                    ;
                        
                        
Patricia A,Peyser                                    [24]
                                    ;
                        
                        
Sharon L R,Kardia                                    [24]
                                    ;
                        
                        
Lyle J,Palmer                                    [124]
                                    ;
                        
                        
Brenda W,Penninx                                    [9]
                                    ;
                        
                        
Pierre,Meneton                                    [125]
                                    ;
                        
                        
Tamara B,Harris                                    [126]
                                    ;
                        
                        
Gerjan,Navis                                    [86]
                                    ;
                        
                        
Pim van der,Harst                                    [127]
                                    ;
                        
                        
George Davey,Smith                                    [128]
                                    ;
                        
                        
Nita G,Forouhi                                    [5]
                                    ;
                        
                        
Ruth J F,Loos                                    [129]
                                    ;
                        
                        
Veikko,Salomaa                                    [130]
                                    ;
                        
                        
Nicole,Soranzo                                    [29]
                                    ;
                        
                        
Dorret I,Boomsma                                    [67]
                                    ;
                        
                        
Leif,Groop                                    [131]
                                    ;
                        
                        
Tiinamaija,Tuomi                                    [132]
                                    ;
                        
                        
Albert,Hofman                                    [133]
                                    ;
                        
                        
Patricia B,Munroe                                    [37]
                                    ;
                        
                        
Vilmundur,Gudnason                                    [134]
                                    ;
                        
                        
David S,Siscovick                                    [135]
                                    ;
                        
                        
Hugh,Watkins                                    [34]
                                    ;
                        
                        
Cecile,Lecoeur                                    [136]
                                    ;
                        
                        
Peter,Vollenweider                                    [137]
                                    ;
                        
                        
Anders,Franco-Cereceda                                    [138]
                                    ;
                        
                        
Per,Eriksson                                    [13]
                                    ;
                        
                        
Marjo-Riitta,Jarvelin                                    [139]
                                    ;
                        
                        
Kari,Stefansson                                    [140]
                                    ;
                        
                        
Anders,Hamsten                                    [141]
                                    ;
                        
                        
George,Nicholson                                    [142]
                                    ;
                        
                        
Fredrik,Karpe                                    [143]
                                    ;
                        
                        
Emmanouil T,Dermitzakis                                    [144]
                                    ;
                        
                        
Cecilia M,Lindgren                                    [145]
                                    ;
                        
                        
Mark I,McCarthy                                    [146]
                                    ;
                        
                        
Philippe,Froguel                                    [15]
                                    ;
                        
                        
Marika A,Kaakinen                                    [147]
                                    ;
                        
                        
Valeriya,Lyssenko                                    [148]
                                    ;
                        
                        
Richard M,Watanabe                                    [149]
                                    ;
                        
                        
Erik,Ingelsson                                    [150]
                                    ;
                        
                        
Jose C,Florez                                    [151]
                                    ;
                        
                        
Josée,Dupuis                                    [152]
                                    ;
                        
                        
Inês,Barroso                                    [153]
                                    ;
                        
                        
Andrew P,Morris                                    [154]
                                    ;
                        
                        
Inga,Prokopenko                                    [155]
                                    ;
                        
                        
Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
                        
                
                
            
            
                作者单位:
                
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.;VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
                            [1]
                        
                        
                            Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia.
                            [2]
                        
                        
                            Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.;Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands.
                            [3]
                        
                        
                            Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD, München-Neuherberg, Germany.
                            [4]
                        
                        
                            MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.
                            [5]
                        
                        
                            University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France.
                            [6]
                        
                        
                            Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy.
                            [7]
                        
                        
                            Boston University Data Coordinating Center, Boston, MA, USA.
                            [8]
                        
                        
                            Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands.
                            [9]
                        
                        
                            MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Bristol Medical School, University of Bristol, Bristol, United Kingdom.
                            [10]
                        
                        
                            Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece.
                            [11]
                        
                        
                            Department of Medicine, Imperial College London, London, UK.
                            [12]
                        
                        
                            Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden.
                            [13]
                        
                        
                            Department of Medicine, Imperial College London, London, UK.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
                            [14]
                        
                        
                            University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;Department of Medicine, Imperial College London, London, UK.
                            [15]
                        
                        
                            Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
                            [16]
                        
                        
                            Université de Lorraine, IGE-PCV, F-54000, Nancy, France.
                            [17]
                        
                        
                            Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.;Department of Physiology, Maastricht University, Maastricht, the Netherlands.
                            [18]
                        
                        
                            Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.
                            [19]
                        
                        
                            MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.
                            [20]
                        
                        
                            Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA.
                            [21]
                        
                        
                            Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.
                            [22]
                        
                        
                            Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.
                            [23]
                        
                        
                            Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
                            [24]
                        
                        
                            Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia.
                            [25]
                        
                        
                            Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Department of Genetics, Harvard Medical School, Boston, MA, USA.;Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA.
                            [26]
                        
                        
                            Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
                            [27]
                        
                        
                            Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.
                            [28]
                        
                        
                            Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.
                            [29]
                        
                        
                            Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.
                            [30]
                        
                        
                            Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.;Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland.
                            [31]
                        
                        
                            Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.;Department of Medicine, University of Washington, Seattle, WA, USA.
                            [32]
                        
                        
                            Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.
                            [33]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK.
                            [34]
                        
                        
                            Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.
                            [35]
                        
                        
                            Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.;Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK.
                            [36]
                        
                        
                            William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.
                            [37]
                        
                        
                            Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland.
                            [38]
                        
                        
                            deCODE Genetics, Reykjavik, Iceland.
                            [39]
                        
                        
                            Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.;Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.;Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK.
                            [40]
                        
                        
                            Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.
                            [41]
                        
                        
                            Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.
                            [42]
                        
                        
                            Usher Institute, University of Edinburgh, Edinburgh, UK.;Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK.
                            [43]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA.
                            [44]
                        
                        
                            William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;Wellcome Trust Sanger Institute, Hinxton, UK.
                            [45]
                        
                        
                            Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden.
                            [46]
                        
                        
                            Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
                            [47]
                        
                        
                            Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
                            [48]
                        
                        
                            Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
                            [49]
                        
                        
                            Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.;Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.;Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany.
                            [50]
                        
                        
                            Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA.
                            [51]
                        
                        
                            Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland.
                            [52]
                        
                        
                            University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia.
                            [53]
                        
                        
                            Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.;Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.;Department of Odontology, Umeå University, Umeå, Sweden.
                            [54]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan.
                            [55]
                        
                        
                            Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA.
                            [56]
                        
                        
                            Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
                            [57]
                        
                        
                            Department of Medicine, University of Leipzig, Leipzig, Germany.;IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
                            [58]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Wellcome Trust Sanger Institute, Hinxton, UK.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
                            [59]
                        
                        
                            Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
                            [60]
                        
                        
                            Faculty of Medicine, University of Split, Split, Croatia.
                            [61]
                        
                        
                            Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands.
                            [62]
                        
                        
                            IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.
                            [63]
                        
                        
                            Usher Institute, University of Edinburgh, Edinburgh, UK.
                            [64]
                        
                        
                            Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA.
                            [65]
                        
                        
                            IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.;Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany.
                            [66]
                        
                        
                            Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.
                            [67]
                        
                        
                            Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland.
                            [68]
                        
                        
                            Department of Dietetics-Nutrition, Harokopio University, Athens, Greece.
                            [69]
                        
                        
                            Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.
                            [70]
                        
                        
                            Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.;Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland.
                            [71]
                        
                        
                            Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy.
                            [72]
                        
                        
                            German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
                            [73]
                        
                        
                            Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA.
                            [74]
                        
                        
                            Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA.
                            [75]
                        
                        
                            Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden.
                            [76]
                        
                        
                            Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK.
                            [77]
                        
                        
                            Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.;Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Estonian Genome Center, University of Tartu, Tartu, Estonia.
                            [78]
                        
                        
                            Department of Epidemiology and Public Health, University College London, London, UK.
                            [79]
                        
                        
                            Department of Epidemiology and Public Health, University College London, London, UK.;University of Essex, Wivenhoe Park, Colchester, Essex, UK.
                            [80]
                        
                        
                            Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.
                            [81]
                        
                        
                            German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.;Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.
                            [82]
                        
                        
                            Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.;Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.;Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland.
                            [83]
                        
                        
                            Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.
                            [84]
                        
                        
                            Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
                            [85]
                        
                        
                            Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
                            [86]
                        
                        
                            Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland.
                            [87]
                        
                        
                            Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.;Netherlands Heart Institute, Utrecht, the Netherlands.
                            [88]
                        
                        
                            Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom.
                            [89]
                        
                        
                            Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.;PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland.
                            [90]
                        
                        
                            IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.;Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA.
                            [91]
                        
                        
                            Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA.
                            [92]
                        
                        
                            Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden.
                            [93]
                        
                        
                            Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.
                            [94]
                        
                        
                            Department of Medicine, University of Leipzig, Leipzig, Germany.;Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.
                            [95]
                        
                        
                            Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands.
                            [96]
                        
                        
                            Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.
                            [97]
                        
                        
                            Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.;Novo Nordisk A/S, Copenhagen, Denmark.
                            [98]
                        
                        
                            Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland.
                            [99]
                        
                        
                            MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.;Usher Institute, University of Edinburgh, Edinburgh, UK.
                            [100]
                        
                        
                            Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.
                            [101]
                        
                        
                            Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.;Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.;German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany.
                            [102]
                        
                        
                            Cardiology Group, Frankfurt-Sachsenhausen, Germany.
                            [103]
                        
                        
                            Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore.
                            [104]
                        
                        
                            Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.;Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany.
                            [105]
                        
                        
                            William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;Wellcome Trust Sanger Institute, Hinxton, UK.;Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia.
                            [106]
                        
                        
                            IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.;Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
                            [107]
                        
                        
                            Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.;Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland.
                            [108]
                        
                        
                            Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.;Unit of General Practice, Oulu University Hospital, Oulu, Finland.
                            [109]
                        
                        
                            Finnish Diabetes Association, Tampere, Finland.;Pirkanmaa Hospital District, Tampere, Finland.
                            [110]
                        
                        
                            Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA.
                            [111]
                        
                        
                            Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.;Department of Public Health, University of Helsinki, Helsinki, Finland.;Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.;Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia.
                            [112]
                        
                        
                            Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.;Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden.
                            [113]
                        
                        
                            Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Public Health, University of Helsinki, Helsinki, Finland.
                            [114]
                        
                        
                            Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.;Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France.
                            [115]
                        
                        
                            Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA.
                            [116]
                        
                        
                            Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Centre for Medical Systems Biology, Leiden, the Netherlands.
                            [117]
                        
                        
                            Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
                            [118]
                        
                        
                            Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.;Institute of Human Genetics, Hannover Medical School, Hannover, Germany.
                            [119]
                        
                        
                            Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA.
                            [120]
                        
                        
                            Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.;Department of Neurology, General Central Hospital, Bolzano, Italy.;Department of Neurology, University of Lübeck, Lübeck, Germany.
                            [121]
                        
                        
                            Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK.
                            [122]
                        
                        
                            Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.;The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA.
                            [123]
                        
                        
                            School of Public Health, University of Adelaide, Adelaide, Australia.
                            [124]
                        
                        
                            U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France.
                            [125]
                        
                        
                            Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA.
                            [126]
                        
                        
                            Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands.
                            [127]
                        
                        
                            MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK.
                            [128]
                        
                        
                            MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.;The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
                            [129]
                        
                        
                            Finnish Institute for Health and Welfare, Helsinki, Finland.
                            [130]
                        
                        
                            Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.
                            [131]
                        
                        
                            Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.;Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.;Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland.
                            [132]
                        
                        
                            Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.;Netherlands Consortium for healthy ageing, the Hague, the Netherlands.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA.
                            [133]
                        
                        
                            Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine University of Iceland, Reykjavik, Iceland.
                            [134]
                        
                        
                            Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.;Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA.
                            [135]
                        
                        
                            University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.
                            [136]
                        
                        
                            Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland.
                            [137]
                        
                        
                            Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden.
                            [138]
                        
                        
                            Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.;Institue of Health Sciences, University of Oulu, Oulu, Finland.
                            [139]
                        
                        
                            deCODE Genetics, Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, Reykjavík, Iceland.
                            [140]
                        
                        
                            Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.;Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.;Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden.
                            [141]
                        
                        
                            Department of Statistics, University of Oxford, Oxford, UK.
                            [142]
                        
                        
                            Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.
                            [143]
                        
                        
                            Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland.
                            [144]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK.
                            [145]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.;Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA.
                            [146]
                        
                        
                            Department of Medicine, Imperial College London, London, UK.;School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK.
                            [147]
                        
                        
                            Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.;Department of Clinical Science, University of Bergen, Bergen, Norway.
                            [148]
                        
                        
                            Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.;Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.;USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA.
                            [149]
                        
                        
                            Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.;Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA.
                            [150]
                        
                        
                            Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA.
                            [151]
                        
                        
                            Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA.
                            [152]
                        
                        
                            Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.;University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.;Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK.
                            [153]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Estonian Genome Center, University of Tartu, Tartu, Estonia.;Department of Biostatistics, University of Liverpool, Liverpool, UK.;Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK.
                            [154]
                        
                        
                            Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.;Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.;School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.;Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk.
                            [155]
                        
                
                
            
        
			主题词
			成年人(Adult);神经性厌食(Anorexia Nervosa);血糖(Blood Glucose);禁食(Fasting);女(雌)性(Female);基因表达(Gene Expression);基因座(Genetic Loci);全基因组关联研究(Genome-Wide Association Study);葡糖耐受不良(Glucose Intolerance);人类(Humans);胰岛素(Insulin);胰岛素受体底物蛋白质类(Insulin Receptor Substrate Proteins);胰岛素抗药性(Insulin Resistance);Kruppel样转录因子类(Kruppel-Like Transcription Factors);男(雄)性(Male);中年人(Middle Aged);表型(Phenotype);性征(Sex Characteristics);性别因素(Sex Factors);腰臀比(Waist-Hip Ratio)
		
        		
			DOI
			10.1038/s41467-020-19366-9
		
        		
			PMID
			33402679
		
        		
			发布时间
			2025-05-30
		
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                Nature communications
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