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Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability.

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第一作者: Vasiliki,Lagou
第一单位: Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.;VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium.
作者: Vasiliki,Lagou [1] ; Reedik,Mägi [2] ; Jouke- Jan,Hottenga [3] ; Harald,Grallert [4] ; John R B,Perry [5] ; Nabila,Bouatia-Naji [6] ; Letizia,Marullo [7] ; Denis,Rybin [8] ; Rick,Jansen [9] ; Josine L,Min [10] ; Antigone S,Dimas [11] ; Anna,Ulrich [12] ; Liudmila,Zudina [12] ; Jesper R,Gådin [13] ; Longda,Jiang [14] ; Alessia,Faggian [12] ; Amélie,Bonnefond [15] ; Joao,Fadista [16] ; Maria G,Stathopoulou [17] ; Aaron,Isaacs [18] ; Sara M,Willems [19] ; Pau,Navarro [20] ; Toshiko,Tanaka [21] ; Anne U,Jackson [22] ; May E,Montasser [23] ; Jeff R,O'Connell [23] ; Lawrence F,Bielak [24] ; Rebecca J,Webster [25] ; Richa,Saxena [26] ; Jeanette M,Stafford [27] ; Beate St,Pourcain [10] ; Nicholas J,Timpson [10] ; Perttu,Salo [28] ; So-Youn,Shin [29] ; Najaf,Amin [30] ; Albert V,Smith [31] ; Guo,Li [32] ; Niek,Verweij [33] ; Anuj,Goel [34] ; Ian,Ford [35] ; Paul C D,Johnson [36] ; Toby,Johnson [37] ; Karen,Kapur [38] ; Gudmar,Thorleifsson [39] ; Rona J,Strawbridge [40] ; Laura J,Rasmussen-Torvik [41] ; Tõnu,Esko [2] ; Evelin,Mihailov [2] ; Tove,Fall [42] ; Ross M,Fraser [43] ; Anubha,Mahajan [44] ; Stavroula,Kanoni [45] ; Vilmantas,Giedraitis [46] ; Marcus E,Kleber [47] ; Günther,Silbernagel [48] ; Julia,Meyer [49] ; Martina,Müller-Nurasyid [50] ; Andrea,Ganna [51] ; Antti-Pekka,Sarin [52] ; Loic,Yengo [53] ; Dmitry,Shungin [54] ; Jian'an,Luan [5] ; Momoko,Horikoshi [55] ; Ping,An [56] ; Serena,Sanna [57] ; Yvonne,Boettcher [58] ; N William,Rayner [59] ; Ilja M,Nolte [60] ; Tatijana,Zemunik [61] ; Erik van,Iperen [62] ; Peter,Kovacs [63] ; Nicholas D,Hastie [20] ; Sarah H,Wild [64] ; Stela,McLachlan [64] ; Susan,Campbell [20] ; Ozren,Polasek [61] ; Olga,Carlson [65] ; Josephine,Egan [65] ; Wieland,Kiess [66] ; Gonneke,Willemsen [67] ; Johanna,Kuusisto [68] ; Markku,Laakso [68] ; Maria,Dimitriou [69] ; Andrew A,Hicks [70] ; Rainer,Rauramaa [71] ; Stefania,Bandinelli [72] ; Barbara,Thorand [73] ; Yongmei,Liu [74] ; Iva,Miljkovic [75] ; Lars,Lind [76] ; Alex,Doney [77] ; Markus,Perola [78] ; Aroon,Hingorani [79] ; Mika,Kivimaki [79] ; Meena,Kumari [80] ; Amanda J,Bennett [81] ; Christopher J,Groves [81] ; Christian,Herder [82] ; Heikki A,Koistinen [83] ; Leena,Kinnunen [84] ; Ulf de,Faire [85] ; Stephan J L,Bakker [86] ; Matti,Uusitupa [87] ; Colin N A,Palmer [77] ; J Wouter,Jukema [88] ; Naveed,Sattar [89] ; Anneli,Pouta [90] ; Harold,Snieder [60] ; Eric,Boerwinkle [91] ; James S,Pankow [92] ; Patrik K,Magnusson [93] ; Ulrika,Krus [94] ; Chiara,Scapoli [7] ; Eco J C N,de Geus [3] ; Matthias,Blüher [95] ; Bruce H R,Wolffenbuttel [96] ; Michael A,Province [56] ; Goncalo R,Abecasis [22] ; James B,Meigs [97] ; G Kees,Hovingh [98] ; Jaana,Lindström [99] ; James F,Wilson [100] ; Alan F,Wright [20] ; George V,Dedoussis [69] ; Stefan R,Bornstein [101] ; Peter E H,Schwarz [102] ; Anke,Tönjes [58] ; Bernhard R,Winkelmann [103] ; Bernhard O,Boehm [104] ; Winfried,März [105] ; Andres,Metspalu [2] ; Jackie F,Price [64] ; Panos,Deloukas [106] ; Antje,Körner [107] ; Timo A,Lakka [108] ; Sirkka M,Keinanen-Kiukaanniemi [109] ; Timo E,Saaristo [110] ; Richard N,Bergman [111] ; Jaakko,Tuomilehto [112] ; Nicholas J,Wareham [5] ; Claudia,Langenberg [5] ; Satu,Männistö [84] ; Paul W,Franks [113] ; Caroline,Hayward [20] ; Veronique,Vitart [20] ; Jaakko,Kaprio [114] ; Sophie,Visvikis-Siest [17] ; Beverley,Balkau [115] ; David,Altshuler [116] ; Igor,Rudan [64] ; Michael,Stumvoll [58] ; Harry,Campbell [64] ; Cornelia M,van Duijn [117] ; Christian,Gieger [118] ; Thomas,Illig [119] ; Luigi,Ferrucci [120] ; Nancy L,Pedersen [93] ; Peter P,Pramstaller [121] ; Michael,Boehnke [22] ; Timothy M,Frayling [122] ; Alan R,Shuldiner [123] ; Patricia A,Peyser [24] ; Sharon L R,Kardia [24] ; Lyle J,Palmer [124] ; Brenda W,Penninx [9] ; Pierre,Meneton [125] ; Tamara B,Harris [126] ; Gerjan,Navis [86] ; Pim van der,Harst [127] ; George Davey,Smith [128] ; Nita G,Forouhi [5] ; Ruth J F,Loos [129] ; Veikko,Salomaa [130] ; Nicole,Soranzo [29] ; Dorret I,Boomsma [67] ; Leif,Groop [131] ; Tiinamaija,Tuomi [132] ; Albert,Hofman [133] ; Patricia B,Munroe [37] ; Vilmundur,Gudnason [134] ; David S,Siscovick [135] ; Hugh,Watkins [34] ; Cecile,Lecoeur [136] ; Peter,Vollenweider [137] ; Anders,Franco-Cereceda [138] ; Per,Eriksson [13] ; Marjo-Riitta,Jarvelin [139] ; Kari,Stefansson [140] ; Anders,Hamsten [141] ; George,Nicholson [142] ; Fredrik,Karpe [143] ; Emmanouil T,Dermitzakis [144] ; Cecilia M,Lindgren [145] ; Mark I,McCarthy [146] ; Philippe,Froguel [15] ; Marika A,Kaakinen [147] ; Valeriya,Lyssenko [148] ; Richard M,Watanabe [149] ; Erik,Ingelsson [150] ; Jose C,Florez [151] ; Josée,Dupuis [152] ; Inês,Barroso [153] ; Andrew P,Morris [154] ; Inga,Prokopenko [155] ; Meta-Analyses of Glucose and Insulin-related traits Consortium (MAGIC)
作者单位: Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Department of Microbiology and Immunology, Laboratory of Adaptive Immunity, KU Leuven, Leuven, Belgium.;VIB-KU Leuven Center for Brain and Disease Research, Leuven, Belgium. [1] Estonian Genome Centre, Institute of Genomics, University of Tartu, Tartu, Estonia. [2] Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands.;Amsterdam Public Health Research Institute, VU University medical center, Amsterdam, the Netherlands. [3] Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD, München-Neuherberg, Germany. [4] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom. [5] University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;INSERM U970, Paris Cardiovascular Research Center PARCC, 75006, Paris, France. [6] Department of Life Sciences and Biotechnology, University of Ferrara, Ferrara, Italy. [7] Boston University Data Coordinating Center, Boston, MA, USA. [8] Department of Psychiatry, VU University Medical Center, Amsterdam, the Netherlands. [9] MRC Integrative Epidemiology Unit, University of Bristol, Bristol, UK.;Bristol Medical School, University of Bristol, Bristol, United Kingdom. [10] Institute for Bioinnovation, Biomedical Sciences Research Center Al. Fleming, Vari, Greece. [11] Department of Medicine, Imperial College London, London, UK. [12] Cardiovascular Medicine Unit, Center for Molecular Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Karolinska University Hospital, Solna, Sweden. [13] Department of Medicine, Imperial College London, London, UK.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. [14] University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;Department of Medicine, Imperial College London, London, UK. [15] Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark. [16] Université de Lorraine, IGE-PCV, F-54000, Nancy, France. [17] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;CARIM School for Cardiovascular Diseases and Maastricht Centre for Systems Biology (MaCSBio, Maastricht University, Maastricht, the Netherlands.;Department of Physiology, Maastricht University, Maastricht, the Netherlands. [18] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands. [19] MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK. [20] Translational Gerontology Branch, Longitudinal Study Section, National Institute on Aging, Baltimore, MD, USA. [21] Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA. [22] Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA. [23] Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA. [24] Laboratory for Cancer Medicine, Harry Perkins Institute of Medical Research, University of Western Australia Centre for Medical Research, Nedlands, WA, Australia. [25] Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Department of Genetics, Harvard Medical School, Boston, MA, USA.;Departmentartment of Anesthesia, Critical Care and Pain Medicine, MGH, Boston, MA, USA. [26] Department of Biostatistics and Data Science, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. [27] Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland. [28] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK. [29] Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands. [30] Department of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI, USA.;Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine, University of Iceland, Reykjavik, Iceland. [31] Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.;Department of Medicine, University of Washington, Seattle, WA, USA. [32] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands. [33] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, UK. [34] Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK. [35] Robertson Centre for Biostatistics, University of Glasgow, Glasgow, UK.;Institute of Biodiversity, Animal Health & Comparative Medicine, University of Glasgow, Glasgow, UK. [36] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;NIHR Barts Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK. [37] Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland. [38] deCODE Genetics, Reykjavik, Iceland. [39] Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.;Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.;Institute of Health and Wellbeing, University of Glasgow, Glasgow, UK. [40] Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA. [41] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden. [42] Usher Institute, University of Edinburgh, Edinburgh, UK.;Synpromics Ltd, Roslin Innovation Centre, Easter Bush Campus, Edinburgh, EH25 9RG, UK. [43] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA. [44] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;Wellcome Trust Sanger Institute, Hinxton, UK. [45] Department of Public Health and Caring Sciences, Uppsala Universitet, Uppsala, Sweden. [46] Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany. [47] Division of Angiology, Department of Internal Medicine, Medical University of Graz, Graz, Austria. [48] Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [49] Institute of Genetic Epidemiology,Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.;Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology and Chair of Genetic Epidemiology, Ludwig-Maximilians-Universität, Munich, Germany.;Department of Medicine I, University Hospital Grosshadern, Ludwig-Maximilians-University, Munich, Germany.;Institute of Medical Biostatistics, Epidemiology and Informatics (IMBEI, University Medical Center, Johannes Gutenberg University, 55101, Mainz, Germany. [50] Analytic and Translational Genetics Unit, Massachusetts General Hospital, Boston, MA, USA.;Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. [51] Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Public Health Genomics Unit, Finnish Institute for Health and Welfare, Helsinki, Finland. [52] University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France.;Institute for Molecular Bioscience, The University of Queensland, Brisbane, QLD, 4072, Australia. [53] Department of Public Health & Clinical Medicine, Umeå University, Umeå, Sweden.;Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.;Department of Odontology, Umeå University, Umeå, Sweden. [54] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;RIKEN, Center for Integrative Medical Sciences, Laboratory for Endocrinology, Metabolism and Kidney Disease, Yokohama, Japan. [55] Division of Statistical Genomics, Washington University School of Medicine, St. Louis, MO, USA. [56] Istituto di Ricerca Genetica e Biomedica, CNR, Monserrato, Italy.;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [57] Department of Medicine, University of Leipzig, Leipzig, Germany.;IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. [58] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Wellcome Trust Sanger Institute, Hinxton, UK.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [59] Department of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [60] Faculty of Medicine, University of Split, Split, Croatia. [61] Department of Clinical Epidemiology and Biostatistics, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands. [62] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany. [63] Usher Institute, University of Edinburgh, Edinburgh, UK. [64] Laboratory of Clinical Investigation, National Institute of Aging, Baltimore, MD, USA. [65] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.;Pediatric Research Center, Department of Women's & Child Health, University of Leipzig, Leipzig, Germany. [66] Department of Biological Psychology, Vrije Universiteit, Amsterdam, the Netherlands. [67] Department of Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio, Finland. [68] Department of Dietetics-Nutrition, Harokopio University, Athens, Greece. [69] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy. [70] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.;Department of Clinical Physiology and Nuclear Medicine, Kuopio University Hospital, Kuopio, Finland. [71] Geriatric Unit, Azienda Sanitaria Firenze (ASF), Florence, Italy. [72] German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [73] Department of Epidemiology and Prevention, Division of Public Health Sciences, Wake Forest University School of Medicine, Winston-Salem, NC, USA. [74] Department of Epidemiology, Center for Aging and Population Health, University of Pittsburgh, Pittsburgh, PA, USA. [75] Department of Medical Sciences, Uppsala University, Akademiska sjukhuset, Uppsala, Sweden. [76] Pat McPherson Centre for Pharmacogenetics and Pharmacogenomics, Division of Molecular and Clinical Medicine, Ninewells Hospital and Medical School, University of Dundee, Dundee, UK. [77] Public Health Genomics Unit, Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.;Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Estonian Genome Center, University of Tartu, Tartu, Estonia. [78] Department of Epidemiology and Public Health, University College London, London, UK. [79] Department of Epidemiology and Public Health, University College London, London, UK.;University of Essex, Wivenhoe Park, Colchester, Essex, UK. [80] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. [81] German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Clinical Diabetology, German Diabetes Center, Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf, Düsseldorf, Germany.;Division of Endocrinology and Diabetology, Medical Faculty, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. [82] Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland.;Department of Medicine, University of Helsinki and Helsinki University Central Hospital, P.O. Box 340, Haartmaninkatu 4, Helsinki, FI-00029, Finland.;Minerva Foundation Institute for Medical Research, Biomedicum 2U, Tukholmankatu 8, Helsinki, FI-00290, Finland. [83] Department of Public Health Solutions, Finnish Institute for Health and Welfare, P.O. Box 30, Helsinki, FI-00271, Finland. [84] Division of Cardiovascular Epidemiology, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden. [85] Department of Internal Medicine, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [86] Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Kuopio, Finland. [87] Dept of Cardiology, Leiden University Medical Center, Leiden, the Netherlands.;Netherlands Heart Institute, Utrecht, the Netherlands. [88] Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, United Kingdom. [89] Department of Government Services, Finnish Institute for Health and Welfare, Helsinki, Finland.;PEDEGO Research Unit, Medical Research Center Oulu, Oulu University Hospital and University of Oulu, Oulu, Finland. [90] IMM Center for Human Genetics, University of Texas Health Science Center at Houston, Houston, TX, USA.;Division of Epidemiology, School of Public Health, University of Texas Health Science Center at Houston, Houston, TX, USA. [91] Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MiI, USA. [92] Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden. [93] Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden. [94] Department of Medicine, University of Leipzig, Leipzig, Germany.;Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA. [95] Department of Endocrinology, University of Groningen, University Medical Center Groningen, Groningen, the Netherlands. [96] Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA.;General Medicine Division, Massachusetts General Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA. [97] Department of Vascular Medicine, Amsterdam UMC, Amsterdam, the Netherlands.;Novo Nordisk A/S, Copenhagen, Denmark. [98] Finnish Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland. [99] MRC Human Genetics Unit, MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Western General Hospital, Edinburgh, UK.;Usher Institute, University of Edinburgh, Edinburgh, UK. [100] Department of Medicine, Division for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany. [101] Department for Prevention and Care of Diabetes, Faculty of Medicine Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.;Paul Langerhans Institute Dresden of the Helmholtz Center Munich at University Hospital and Faculty of Medicine, TU Dresden, Dresden, Germany.;German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany. [102] Cardiology Group, Frankfurt-Sachsenhausen, Germany. [103] Lee Kong Chian School of Medicine, Nanyang Technological University Singapore and Imperial College London, Singapore, Singapore. [104] Vth Department of Medicine, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.;Synlab Academy, Synlab Holding Deutschland GmbH, Mannheim, Germany. [105] William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London, UK.;Wellcome Trust Sanger Institute, Hinxton, UK.;Princess Al-Jawhara Al-Brahim Centre of Excellence in Research of Hereditary Disorders (PACER-HD, King Abdulaziz University, Jeddah, Saudi Arabia. [106] IFB AdiposityDiseases, University of Leipzig, Leipzig, Germany.;Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA. [107] Kuopio Research Institute of Exercise Medicine, Kuopio, Finland.;Institute of Biomedicine/Physiology, University of Eastern Finland, Kuopio Campus, Kuopio, Finland. [108] Faculty of Medicine, Center for Life Course Health Research, University of Oulu, Oulu, Finland.;Unit of General Practice, Oulu University Hospital, Oulu, Finland. [109] Finnish Diabetes Association, Tampere, Finland.;Pirkanmaa Hospital District, Tampere, Finland. [110] Diabetes and Obesity Research Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA. [111] Department of Chronic Disease Prevention, Finnish Institute for Health and Welfare, Helsinki, Finland.;Department of Public Health, University of Helsinki, Helsinki, Finland.;Centre for Vascular Prevention, Danube-University Krems, Krems, Austria.;Diabetes Research Group, King Abdulaziz University, Jeddah, Saudi Arabia. [112] Department of Clinical Sciences, Genetic and Molecular Epidemiology Unit, Skåne University Hospital Malmö, Malmö, Sweden.;Department of Nutrition, Harvard School of Public Health, Boston, MA, USA.;Department of Public Health & Clinical Medicine, Units of Medicine and Nutritional Research, Umeå University, Umeå, Sweden. [113] Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Public Health, University of Helsinki, Helsinki, Finland. [114] Inserm, CESP Center for Research in Epidemiology and Public Health, U1018, Villejuif, France.;Univ Paris-Saclay, Univ Paris Sud, UVSQ, UMRS 1018, UMRS 1018, Villejuif, France. [115] Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Department of Medicine, Harvard Medical School, Boston, MA, USA. [116] Genetic Epidemiology Unit, Department of Epidemiology, Erasmus Medical Center, Rotterdam, the Netherlands.;Centre for Medical Systems Biology, Leiden, the Netherlands. [117] Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;German Center for Diabetes Research (DZD, München-Neuherberg, Germany.;Institute of Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany. [118] Research Unit of Molecular Epidemiology, Institute of Epidemiology, Helmholtz Zentrum München Research Center for Environmental Health, Neuherberg, Germany.;Hannover Unified Biobank, Hannover Medical School, Hannover, Germany.;Institute of Human Genetics, Hannover Medical School, Hannover, Germany. [119] Clinical Research Branch, National Institute on Aging, Baltimore, Maryland, USA. [120] Center for Biomedicine, European Academy Bozen/Bolzano (EURAC) (Affiliated Institute of the University of LübeckLübeckGermany), Bolzano, Italy.;Department of Neurology, General Central Hospital, Bolzano, Italy.;Department of Neurology, University of Lübeck, Lübeck, Germany. [121] Genetics of Complex Traits, Peninsula Medical School, University of Exeter, Exeter, UK. [122] Division of Endocrinology, Diabetes, and Nutrition, Department of Medicine, University of Maryland, School of Medicine, Baltimore, MD, USA.;The Regeneron Genetics Center, Regeneron Pharmaceuticals, Tarrytown, NY, USA. [123] School of Public Health, University of Adelaide, Adelaide, Australia. [124] U872 Institut National de la Santé et de la Recherche Médicale, Centre de Recherche des Cordeliers, 75006, Paris, France. [125] Geriatric Epidemiology Section, Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, MD, USA. [126] Department of Cardiology, University of Groningen, University Medical Center Groningen, Groningen, The Netherlands.;Department of Genetics, University Medical Center Groningen, University of Groningen, Groningen, the Netherlands. [127] MRC Integrative Epidemiology Unit (IEU), University of Bristol, Bristol, UK. [128] MRC Epidemiology Unit, University of Cambridge School of Clinical Medicine, Cambridge, United Kingdom.;The Charles Bronfman Institute for Personalized Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, USA. [129] Finnish Institute for Health and Welfare, Helsinki, Finland. [130] Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden. [131] Institute for Molecular Medicine Finland, FIMM, University of Helsinki, Helsinki, Finland.;Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.;Endocrinology, Abdominal Centre, University of Helsinki and Helsinki University Hospital, Helsinki, Finland.;Research Program for Clinical and Molecular Metabolism, University of Helsinki and Folkhälsan Research Center, Helsinki, Finland. [132] Department of Epidemiology Erasmus MC, Rotterdam, the Netherlands.;Netherlands Consortium for healthy ageing, the Hague, the Netherlands.;Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, USA. [133] Icelandic Heart Association, Kopavogur, Iceland.;Faculty of Medicine University of Iceland, Reykjavik, Iceland. [134] Cardiovascular Health Research Unit, University of Washington, Seattle, WA, USA.;Department of Medicine, University of Washington, Seattle, WA, USA.;Department of Epidemiology, University of Washington, Seattle, WA, USA. [135] University of Lille Nord de France, Lille, France.;CNRS UMR8199, Institut Pasteur de Lille, Lille, France. [136] Department of Medicine, University Hospital Lausanne, Lausanne, Switzerland. [137] Cardiothoracic Surgery Unit, Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, Sweden. [138] Department of Epidemiology and Biostatistics and HPA-MRC Center, School of Public Health, Imperial College London, London, UK.;Institue of Health Sciences, University of Oulu, Oulu, Finland. [139] deCODE Genetics, Reykjavik, Iceland.;Faculty of Medicine, University of Iceland, Reykjavík, Iceland. [140] Cardiovascular Medicine Unit, Department of Medicine, Solna, Karolinska Institutet, Stockholm, Sweden.;Center for Molecular Medicine, Karolinska University Hospital Solna, Stockholm, Sweden.;Department of Cardiology, Karolinska University Hospital Solna, Stockholm, Sweden. [141] Department of Statistics, University of Oxford, Oxford, UK. [142] Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK. [143] Department of Genetic Medicine and Development, University of Geneva Medical School, Geneva, Switzerland. [144] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, MA, USA.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, University of Oxford, Oxford, UK. [145] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK.;Oxford National Institute for Health Research Biomedical Research Centre, Churchill Hospital, Oxford, UK.;Genentech, 340 Point San Bruno Boulevard, South San Francisco, CA, 94080, USA. [146] Department of Medicine, Imperial College London, London, UK.;School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. [147] Department of Clinical Sciences, Diabetes and Endocrinology Research Unit, University Hospital Malmö, Lund University, Malmö, Sweden.;Department of Clinical Science, University of Bergen, Bergen, Norway. [148] Department of Preventive Medicine, Keck School of Medicine of USC, Los Angeles, CA, USA.;Department of Physiology & Neuroscience, Keck School of Medicine of USC, Los Angeles, CA, USA.;USC Diabetes and Obesity Research Institute, Los Angeles, CA, USA. [149] Department of Medical Sciences, Molecular Epidemiology and Science for Life Laboratory, Uppsala University, Uppsala, Sweden.;Department of Medicine, Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, CA, USA.;Stanford Cardiovascular Institute, Stanford University, Stanford, CA, 94305, USA. [150] Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA, USA.;Diabetes Research Center, Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA. [151] Department of Biostatistics, Boston University School of Public Health, Boston, MA, USA. [152] Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, UK.;University of Cambridge Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Wellcome Trust-MRC Institute of Metabolic Science, Cambridge, UK.;Exeter Centre of ExcEllence in Diabetes (ExCEED), University of Exeter Medical School, Exeter, UK. [153] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom.;Estonian Genome Center, University of Tartu, Tartu, Estonia.;Department of Biostatistics, University of Liverpool, Liverpool, UK.;Centre for Genetics and Genomics Versus Arthritis, Centre for Musculoskeletal Research, The University of Manchester, Manchester, UK. [154] Wellcome Centre for Human Genetics, University of Oxford, Oxford, United Kingdom. i.prokopenko@surrey.ac.uk.;Department of Medicine, Imperial College London, London, UK. i.prokopenko@surrey.ac.uk.;Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK. i.prokopenko@surrey.ac.uk.;School of Biosciences and Medicine, Department of Clinical and Experimental Medicine, University of Surrey, Guildford, UK. i.prokopenko@surrey.ac.uk.;Institute of Biochemistry and Genetics, Ufa Federal Research Centre Russian Academy of Sciences, Ufa, Russian Federation. i.prokopenko@surrey.ac.uk. [155]
DOI 10.1038/s41467-020-19366-9
PMID 33402679
发布时间 2025-05-30
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