Performance of the QPLEX™ Alz plus assay, a novel multiplex kit for screening cerebral amyloid deposition.

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作者： Jong-Chan,Park ^[1] ; Keum Sim,Jung ^[2] ; Jiyeong,Kim ^[3] ; Ji Sung,Jang ^[4] ; Sunghoon,Kwon ^[5] ; Min Soo,Byun ^[5] ; Dahyun,Yi ^[5] ; Gihwan,Byeon ^[5] ; Gijung,Jung ^[6] ; Yu Kyeong,Kim ^[7] ; Dong Young,Lee ^[7] ; Sun-Ho,Han ^[7] ; Inhee,Mook-Jung ^[8]

作者单位： Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. ^[1] Department of Biochemistry & Biomedical Sciences, SNU Dementia Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. ^[2] Department of Biochemistry & Biomedical Sciences, Neuroscience Research Institute, Medical Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. ^[3] Department of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, University College London, London, WC1E 6BT, UK. ^[4] QuantaMatrix Inc., Seoul, 03080, Republic of Korea. ^[5] Department of Neuropsychiatry, Seoul National University Bundang Hospital, Seongnam, 13620, Republic of Korea. ^[6] Department of Neuropsychiatry, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. ^[7] Department of Nuclear Medicine, SMG-SNU Boramae Medical Center, Seoul, 07061, Republic of Korea. ^[8] Department of Neuropsychiatry, Seoul National University Hospital, 101 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. selfpsy@snu.ac.kr. ^[9] Department of Psychiatry, College of medicine, Seoul National University, Seoul, 03080, Republic of Korea. selfpsy@snu.ac.kr. ^[10] Institute of Human Behavioral Medicine, Medical Research Center, Seoul National University, Seoul, 03080, Republic of Korea. selfpsy@snu.ac.kr. ^[11] Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. sunho@snu.ac.kr. ^[12] Department of Biochemistry & Biomedical Sciences, SNU Dementia Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. sunho@snu.ac.kr. ^[13] Department of Biochemistry & Biomedical Sciences, Neuroscience Research Institute, Medical Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. sunho@snu.ac.kr. ^[14] Department of Biochemistry and Biomedical Sciences, College of Medicine, Seoul National University, Seoul, 03080, Republic of Korea. inhee@snu.ac.kr. ^[15] Department of Biochemistry & Biomedical Sciences, SNU Dementia Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. inhee@snu.ac.kr. ^[16] Department of Biochemistry & Biomedical Sciences, Neuroscience Research Institute, Medical Research Center, College of Medicine, Seoul National University, 103 Daehak-ro, Jongno-gu, Seoul, 03080, Republic of Korea. inhee@snu.ac.kr. ^[17]

关键词 Alzheimer’s disease Blood-based biomarker Cerebral amyloid deposition Pittsburgh compound B QPLEX? Alz plus assay

主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);苯胺化合物(Aniline Compounds);人类(Humans);神经变性疾病(Neurodegenerative Diseases);正电子发射断层显像术(Positron-Emission Tomography)

DOI 10.1186/s13195-020-00751-x

PMID 33407839

发布时间 2021-06-24

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