A phage-encoded anti-activator inhibits quorum sensing in Pseudomonas aeruginosa.

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作者： Megha,Shah ^[1] ; Véronique L,Taylor ^[1] ; Diane,Bona ^[1] ; Yvonne,Tsao ^[1] ; Sabrina Y,Stanley ^[2] ; Sheila M,Pimentel-Elardo ^[1] ; Matthew,McCallum ^[3] ; Joseph,Bondy-Denomy ^[4] ; P Lynne,Howell ^[3] ; Justin R,Nodwell ^[1] ; Alan R,Davidson ^[5] ; Trevor F,Moraes ^[6] ; Karen L,Maxwell ^[7]

作者单位： Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. ^[1] Department of Molecular Genetics, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. ^[2] Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada; Program in Molecular Structure & Function, Peter Gilgan Centre for Research and Learning, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada. ^[3] Department of Microbiology and Immunology, University of California, San Francisco, San Francisco, CA 94143, USA. ^[4] Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada; Department of Molecular Genetics, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. ^[5] Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. Electronic address: trevor.moraes@utoronto.ca. ^[6] Department of Biochemistry, University of Toronto, MaRS West Tower, 661 University Avenue, Toronto, ON M5G 1M1, Canada. Electronic address: karen.maxwell@utoronto.ca. ^[7]

关键词 LasR PilB Pseudomonas aeruginosa anti-phage crystallography phage pilus pyocyanin quorum sensing