Crystal structure of AmpC BER and molecular docking lead to the discovery of broad inhibition activities of halisulfates against β-lactamases.

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第一作者： Bo-Gyeong,Jeong

第一单位： Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea.

作者： Bo-Gyeong,Jeong ^[1] ; Jung-Hyun,Na ^[1] ; Da-Woon,Bae ^[1] ; Soo-Bong,Park ^[1] ; Hyi-Seung,Lee ^[2] ; Sun-Shin,Cha ^[1]

作者单位： Department of Chemistry & Nanoscience, Ewha Womans University, Seoul 03760, Republic of Korea. ^[1] Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science and Technology, Busan 49111, Republic of Korea. ^[2]

关键词 AmpC BER BLI, β-lactamase inhibitor Broad-spectrum competitive inhibitors Crystal structure DBO, diazabicyclooctane ES, extended-spectrum Halisulfates MES, 2-(N-morpholino) ethanesulfonic acid Marine natural products Ni-NTA, nickel-nitrilotriacetic acid PBP, penicillin-binding protein R2 loop

DOI 10.1016/j.csbj.2020.12.015

PMID 33425247

发布时间 2021-01-12

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