换一批
换一批Deimmunization of protein therapeutics - Recent advances in experimental and computational epitope prediction and deletion.
第一作者：
Léa V,Zinsli
第一单位：
Institute of Food, Nutrition and Health, ETH Zurich, Zurich, Switzerland.
作者：
关键词
ABR, Antigen-binding regionADA, Anti-drug antibodyANN, Artificial neural networkAPC, Antigen-presenting cellAnti-drug-antibodyB cell epitopeBCR, B cell receptorBab, Binding antibodyCDR, Complementarity determining regionCRISPR, Clustered regularly interspaced short palindromic repeatsDC, Dendritic cellELP, Elastin-like polypeptideEPO, ErythropoietinER, Endoplasmatic reticulumGLK, Gelatin-like proteinHAP, Homo-amino-acid polymerHLA, Human leukocyte antigenHMM, Hidden Markov modelIL, InterleukinIg, ImmunoglobulinImmunogenicityLPS, LipopolysaccharideMHC, Major histocompatibility complexNMR, Nuclear magnetic resonanceNab, Neutralizing antibodyPAMP, Pathogen-associated molecular patternPAS, Polypeptide composed of proline, alanine, and/or serinePBMC, Peripheral blood mononuclear cellPD, PharmacodynamicsPEG, Polyethylene glycolPK, PharmacokineticsPRR, Pattern recognition receptorPSA, Sialic acid polymersProtein therapeuticRNN, Recurrent artificial neural networkSVM, Support vector machineT cell epitopeTAP, Transporter associated with antigen processingTCR, T cell receptorTLR, Toll-like receptorXTEN, “Xtended” recombinant polypeptide
DOI
10.1016/j.csbj.2020.12.024
PMID
33425259
发布时间
2023-11-10
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