首页> GeroScience> SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome.

SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome.

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第一作者： Renuka,Kandhaya-Pillai

第一单位： Department of Pathology, University of Washington, Box 357470, HSB, Seattle, WA, K-543, USA.

作者： Renuka,Kandhaya-Pillai ^[1] ; Deyin,Hou ^[1] ; Jiaming,Zhang ^[1] ; Xiaomeng,Yang ^[1] ; Goli,Compoginis ^[2] ; Takayasu,Mori ^[3] ; Tamara,Tchkonia ^[4] ; George M,Martin ^[1] ; Fuki M,Hisama ^[5] ; James L,Kirkland ^[4] ; Junko,Oshima ^[6]

作者单位： Department of Pathology, University of Washington, Box 357470, HSB, Seattle, WA, K-543, USA. ^[1] Department of Dermatology, University of Southern California, Los Angeles, CA, USA. ^[2] Department of Medicine, Tokyo Medical and Dental University, Tokyo, Japan. ^[3] Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, MN, USA. ^[4] Division of Medical Genetics, Department of Medicine, University of Washington, Seattle, WA, USA. ^[5] Department of Pathology, University of Washington, Box 357470, HSB, Seattle, WA, K-543, USA. picard@uw.edu. ^[6]

关键词 Cellular senescence DNA damage Gain of function SMAD4 mutations IFNγ Myhre syndrome Segmental progeroid syndromes TGF-β

主题词隐睾(Cryptorchidism);DNA损伤(DNA Damage);面容(Facies);生长障碍(Growth Disorders);手畸形, 先天性(Hand Deformities, Congenital);人类(Humans);突变(Mutation);Smad4蛋白质(Smad4 Protein);转化生长因子β(Transforming Growth Factor beta)

DOI 10.1007/s11357-020-00318-6

PMID 33428109

发布时间 2022-12-08

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2021年43卷3期

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SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome.

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SMAD4 mutations and cross-talk between TGF-β/IFNγ signaling accelerate rates of DNA damage and cellular senescence, resulting in a segmental progeroid syndrome-the Myhre syndrome.

GeroScience

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GeroScience

相关期刊

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