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Design, synthesis and biological evaluation of novel 2,4-diaryl pyrimidine derivatives as selective EGFR<sup>L858R/T790M</sup> inhibitors.

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第一作者： Jianheng,Li

第一单位： School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China.

作者： Jianheng,Li ^[1] ; Baijiao,An ^[1] ; Xianheng,Song ^[1] ; Qianzhong,Zhang ^[1] ; Chun,Chen ^[1] ; Shuxian,Wei ^[1] ; Runzhu,Fan ^[1] ; Xingshu,Li ^[2] ; Yong,Zou ^[3]

作者单位： School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China. ^[1] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510000, PR China. ^[2] School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, PR China; Guangdong Provincial Key Laboratory of Chiral Molecule and Drug Discovery, Guangzhou 510000, PR China. Electronic address: zouyong3@mail.sysu.edu.cn. ^[3]

关键词 Anti-proliferation Anti-tumor efficacy in?vivo Epidermal growth factor receptor L858R/T790M double mutants Non-small cell lung cancer (NSCLC)