Targeting Germ Cell Tumors with the Newly Synthesized Flavanone-Derived Compound MLo1302 Efficiently Reduces Tumor Cell Viability and Induces Apoptosis and Cell Cycle Arrest.

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作者： João,Lobo ^[1] ; Ana Rita,Cardoso ^[2] ; Vera,Miranda-Gonçalves ^[3] ; Leendert H J,Looijenga ^[4] ; Marie,Lopez ^[1] ; Paola B,Arimondo ^[5] ; Rui,Henrique ^[1] ; Carmen,Jerónimo ^[3]

作者单位： Cancer Biology and Epigenetics Group, IPO Porto Research Center (GEBC CI-IPOP), Portuguese Oncology Institute of Porto (IPO Porto) & Porto Comprehensive Cancer Center (P.CCC), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. ^[1] Department of Pathology, Portuguese Oncology Institute of Porto (IPOP), R. Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal. ^[2] Department of Pathology and Molecular Immunology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513 Porto, Portugal. ^[3] Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS Utrecht, The Netherlands. ^[4] Master in Oncology, Institute of Biomedical Sciences Abel Salazar, University of Porto (ICBAS-UP), Rua Jorge Viterbo Ferreira 228, 4050-513 Porto, Portugal. ^[5] Institut des Biomolécules Max Mousseron (IBMM), CNRS, Université de Montpellier, ENSCM UMR 5247, 34296 Montpellier, France. ^[6] Epigenetic Chemical Biology, Institut Pasteur, CNRS UMR3523, 75724 Paris, France. ^[7]

关键词 DNA methylation cell differentiation drug design epidrugs testicular germ cell tumors

DOI 10.3390/pharmaceutics13010073

PMID 33430420

发布时间 2021-02-18

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