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Natural cystatin C fragments inhibit GPR15-mediated HIV and SIV infection without interfering with GPR15L signaling.

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第一作者： Manuel,Hayn

第一单位： Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany.

作者： Manuel,Hayn ^[1] ; Andrea,Blötz ^[1] ; Armando,Rodríguez ^[2] ; Solange,Vidal ^[3] ; Nico,Preising ^[4] ; Ludger,Ständker ^[4] ; Sebastian,Wiese ^[5] ; Christina M,Stürzel ^[1] ; Mirja,Harms ^[1] ; Rüdiger,Gross ^[1] ; Christoph,Jung ^[6] ; Miriam,Kiene ^[7] ; Timo,Jacob ^[6] ; Stefan,Pöhlmann ^[8] ; Wolf-Georg,Forssmann ^[9] ; Jan,Münch ^[1] ; Konstantin M J,Sparrer ^[1] ; Klaus,Seuwen ^[3] ; Beatrice H,Hahn ^[10] ; Frank,Kirchhoff ^[11]

作者单位： Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany. ^[1] Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany.;Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany.;PHARIS Biotec GmbH, 30625 Hannover, Germany. ^[2] Novartis Institutes for Biomedical Research, 4056 Basel, Switzerland. ^[3] Core Facility Functional Peptidomics, Ulm University Medical Center, 89081 Ulm, Germany. ^[4] Core Unit Mass Spectrometry and Proteomics, Ulm University Medical Center, 89081 Ulm, Germany. ^[5] Institute of Electrochemistry, Ulm University, 89081 Ulm, Germany. ^[6] Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany. ^[7] Infection Biology Unit, German Primate Center-Leibniz Institute for Primate Research, 37077 Göttingen, Germany.;Faculty of Biology and Psychology, University Göttingen, 37073 Göttingen, Germany. ^[8] PHARIS Biotec GmbH, 30625 Hannover, Germany. ^[9] Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076; bhahn@pennmedicine.upenn.edu frank.kirchhoff@uni-ulm.de.;Department of Microbiology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA 19104-6076. ^[10] Institute of Molecular Virology, Ulm University Medical Center, 89081 Ulm, Germany; bhahn@pennmedicine.upenn.edu frank.kirchhoff@uni-ulm.de. ^[11]

关键词 G protein-coupled receptors GPR15 chemokines cystatin C immunodeficiency viruses