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Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems.

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第一作者： Timothy C,Yu

第一单位： Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.

作者： Timothy C,Yu ^[1] ; Winnie L,Liu ^[2] ; Marcia S,Brinck ^[3] ; Jessica E,Davis ^[4] ; Jeremy,Shek ^[4] ; Grace,Bower ^[2] ; Tal,Einav ^[5] ; Kimberly D,Insigne ^[6] ; Rob,Phillips ^[7] ; Sriram,Kosuri ^[8] ; Guillaume,Urtecho ^[9]

作者单位： Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA. ^[1] Department of Molecular, Cell, and Developmental Biology, University of California, Los Angeles, CA, 90095, USA. ^[2] Department of Microbiology, Immunology, and Molecular Genetics, University of California, Los Angeles, CA, 90095, USA. ^[3] Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA. ^[4] Department of Physics, California Institute of Technology, Pasadena, CA, 91125, USA. ^[5] Bioinformatics Interdepartmental Graduate Program, University of California, Los Angeles, CA, 90095, USA. ^[6] Department of Physics, California Institute of Technology, Pasadena, CA, 91125, USA.;Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.;Department of Applied Physics, California Institute of Technology, Pasadena, CA, 91125, USA. ^[7] Department of Chemistry and Biochemistry, University of California, Los Angeles, CA, 90095, USA. sri@ucla.edu.;UCLA-DOE Institute for Genomics and Proteomics, Los Angeles, CA, 90095, USA. sri@ucla.edu.;Institute for Quantitative and Computational Biosciences (QCB), University of California, Los Angeles, Los Angeles, CA, 90095, USA. sri@ucla.edu.;Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, Los Angeles, CA, 90095, USA. sri@ucla.edu.;Jonsson Comprehensive Cancer Center, University of California, Los Angeles, CA, 90095, USA. sri@ucla.edu.;Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, 90095, USA. sri@ucla.edu. ^[8] Molecular Biology Interdepartmental Doctoral Program, University of California, Los Angeles, CA, 90095, USA. gurtecho@ucla.edu. ^[9]