Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique.-论文-万方医学网

作者： Adeyemi T,Kayode ^[1] ; Fehintola V,Ajogbasile ^[2] ; Kazeem,Akano ^[1] ; Jessica N,Uwanibe ^[2] ; Paul E,Oluniyi ^[1] ; Philomena J,Eromon ^[2] ; Onikepe A,Folarin ^[1] ; Akintunde,Sowunmi ^[2] ; Dyann F,Wirth ^[1] ; Christian T,Happi ^[2]

作者单位： African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria. ^[1] Department of Biological Sciences, Redeemer's University, Ede, Nigeria. ^[2] Institute of Advanced Medical Research and Training, College of Medicine, University of Ibadan, Ibadan, Nigeria. ^[3] Department of Pharmacology and Therapeutics, University of Ibadan, Ibadan, Nigeria. ^[4] Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. ^[5] African Centre of Excellence for Genomics of Infectious Diseases, Redeemer's University, Ede, Nigeria. happic@run.edu.ng. ^[6] Department of Biological Sciences, Redeemer's University, Ede, Nigeria. happic@run.edu.ng. ^[7] Department of Immunology and Infectious Diseases, Harvard T.H. Chan School of Public Health, Boston, MA, USA. happic@run.edu.ng. ^[8]

主题词抗原, 原虫(Antigens, Protozoan);抗疟药(Antimalarials);儿童, 学龄前(Child, Preschool);二氢蝶酸合酶(Dihydropteroate Synthase);复方合剂(Drug Combinations);抗药性(Drug Resistance);女(雌)性(Female);基因型(Genotype);单倍型(Haplotypes);人类(Humans);婴儿(Infant);疟疾, 恶性(Malaria, Falciparum);男(雄)性(Male);裂殖子表面蛋白质1(Merozoite Surface Protein 1);尼日利亚(Nigeria);恶性疟原虫(Plasmodium falciparum);聚合酶链反应(Polymerase Chain Reaction);多态现象, 遗传(Polymorphism, Genetic);人群监测(Population Surveillance);原虫蛋白质类(Protozoan Proteins);乙胺嘧啶(Pyrimethamine);序列分析, DNA(Sequence Analysis, DNA);磺胺多辛(Sulfadoxine);四氢叶酸脱氢酶(Tetrahydrofolate Dehydrogenase)

DOI 10.1038/s41598-020-80017-6

PMID 33436791

发布时间 2021-08-16

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Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique.

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Polymorphisms in Plasmodium falciparum dihydropteroate synthetase and dihydrofolate reductase genes in Nigerian children with uncomplicated malaria using high-resolution melting technique.

Scientific reports

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Scientific reports

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