Hsp90/C terminal Hsc70-interacting protein regulates the stability of Ikaros in acute myeloid leukemia cells.

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作者： Meng,Liu ^[1] ; Jin,Jin ^[2] ; Yanjie,Ji ^[1] ; Huizhuang,Shan ^[1] ; Zhihui,Zou ^[1] ; Yang,Cao ^[3] ; Li,Yang ^[1] ; Ligen,Liu ^[1] ; Li,Zhou ^[4] ; Hu,Lei ^[1] ; Yunzhao,Wu ^[1] ; Hanzhang,Xu ^[5] ; Yingli,Wu ^[6]

作者单位： Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[1] Department of Ultrasound, Second Affiliated Hospital of Zhejiang University, Hangzhou, 310009, China. ^[2] Department of Hematology, The Third Affiliated Hospital of Soochow University, Changzhou, 213003, China. ^[3] Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. ^[4] Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. smollyxu@126.com. ^[5] Hongqiao International Institute of Medicine, Shanghai Tongren Hospital/Faculty of Basic Medicine, Chemical Biology Division of Shanghai Universities E-Institutes, Key Laboratory of Cell Differentiation and Apoptosis of the Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, 200025, China. wuyingli@shsmu.edu.cn. ^[6]

关键词 AML CHIP Hsp90 Ikaros STA-9090

主题词醇氧化还原酶类(Alcohol Oxidoreductases);细胞系, 肿瘤(Cell Line, Tumor);DNA结合蛋白质类(DNA-Binding Proteins);减量调节(Down-Regulation);HEK293细胞(HEK293 Cells);HSC70热休克蛋白质类(HSC70 Heat-Shock Proteins);HSP90热休克蛋白质类(HSP90 Heat-Shock Proteins);人类(Humans);Ikaros转录因子(Ikaros Transcription Factor);白血病, 髓样, 急性(Leukemia, Myeloid, Acute);泛素蛋白连接酶类(Ubiquitin-Protein Ligases);泛素化(Ubiquitination)

DOI 10.1007/s11427-020-1860-2

PMID 33439458

发布时间 2022-01-06

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Science China. Life sciences

2021年64卷9期

1481-1490页

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Hsp90/C terminal Hsc70-interacting protein regulates the stability of Ikaros in acute myeloid leukemia cells.

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Hsp90/C terminal Hsc70-interacting protein regulates the stability of Ikaros in acute myeloid leukemia cells.

Science China. Life sciences

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