首页> Translational psychiatry> A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies.

A cortical immune network map identifies distinct microglial transcriptional programs associated with β-amyloid and Tau pathologies.

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第一作者： Ellis,Patrick

第一单位： School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.;The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia.

作者： Ellis,Patrick ^[1] ; Marta,Olah ^[2] ; Mariko,Taga ^[2] ; Hans-Ulrich,Klein ^[2] ; Jishu,Xu ^[3] ; Charles C,White ^[4] ; Daniel,Felsky ^[5] ; Sonal,Agrawal ^[3] ; Chris,Gaiteri ^[3] ; Lori B,Chibnik ^[6] ; Sara,Mostafavi ^[7] ; Julie A,Schneider ^[3] ; David A,Bennett ^[3] ; Elizabeth M,Bradshaw ^[8] ; Philip L,De Jager ^[9]

作者单位： School of Mathematics and Statistics, The University of Sydney, Sydney, NSW, Australia.;The Westmead Institute for Medical Research, The University of Sydney, Sydney, NSW, Australia. ^[1] Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. ^[2] Rush Alzheimer's Disease Center, Rush University Medical Center, Chicago, IL, USA. ^[3] Cell Circuits Program, Broad Institute, Cambridge, MA, USA. ^[4] Krembil Centre for Neuroinformatics, Centre for Addiction and Mental Health, Toronto, ON, Canada.;Department of Psychiatry & Institute of Medical Science, University of Toronto, Toronto, ON, Canada. ^[5] Department of Neurology, Massachusetts General Hospital, Charlestown, MA, USA.;Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA, USA.;Stanley Center for Psychiatric Genetics, Broad Institute of MIT and Harvard, Cambridge, MA, USA. ^[6] Paul Allen School of Computer Science and Engineering, University of Washington, Seattle, WA, USA. ^[7] Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. ^[8] Center for Translational & Computational Neuroimmunology, Department of Neurology, Columbia University Medical Center, New York, NY, USA. pld2115@cumc.columbia.edu.;Taub Institute for Research on Alzheimer's Disease and the Aging Brain, Columbia University Irving Medical Center, New York, NY, USA. pld2115@cumc.columbia.edu.;Cell Circuits Program, Broad Institute, Cambridge, MA, USA. pld2115@cumc.columbia.edu. ^[9]

医学主题词阿尔茨海默病(Alzheimer Disease);淀粉样β肽类(Amyloid beta-Peptides);脑(Brain);人类(Humans);小神经胶质细胞(Microglia);tau蛋白质类(tau Proteins)

DOI 10.1038/s41398-020-01175-9

PMID 33446646

发布时间 2023-12-31

基金项目

U01 AG061356/AG/NIA NIH HHS/United States R01 AG043617/AG/NIA NIH HHS/United States R01 AG017917/AG/NIA NIH HHS/United States R01 AG057911/AG/NIA NIH HHS/United States P30 AG010161/AG/NIA NIH HHS/United States RF1 AG058852/AG/NIA NIH HHS/United States RC2 AG036547/AG/NIA NIH HHS/United States R01 NS089674/NS/NINDS NIH HHS/United States R01 AG061798/AG/NIA NIH HHS/United States U01 AG046152/AG/NIA NIH HHS/United States R01 AG036836/AG/NIA NIH HHS/United States R01 AG015819/AG/NIA NIH HHS/United States

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