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An Autochthonous Mouse Model of Myd88- and BCL2-Driven Diffuse Large B-cell Lymphoma Reveals Actionable Molecular Vulnerabilities.

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第一作者: Ruth,Flümann
第一单位: University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.;Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Center for Molecular Medicine, University of Cologne, Cologne, Germany.;Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.
作者单位: University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.;Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Center for Molecular Medicine, University of Cologne, Cologne, Germany.;Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. [1] Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany. [2] Medical Faculty, Department of Pediatric Oncology, Hematology and Clinical Immunology, Heinrich Heine University Düsseldorf, Düsseldorf, Germany. [3] Department of Pediatrics, Pediatric Hematology and Oncology, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden, Germany.;National Center for Tumor Diseases (NCT), Dresden, Germany. [4] University of Cologne, Faculty of Medicine and University Hospital Cologne, Clinic I of Internal Medicine, Cologne, Germany.;Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. [5] Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. [6] Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum - MKFZ, Virchow Campus, Berlin, Germany. [7] Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany. [8] Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Faculty of Medicine and University Hospital Cologne, Institute of Neuropathology, University of Cologne, Cologne, Germany. [9] Cologne Center for Genomics (CCG), University of Cologne, Cologne, Germany. [10] Faculty of Medicine and University Hospital Cologne, Institute of Clinical Chemistry, University of Cologne, Cologne, Germany. [11] Department of Pathology and Cell Biology, Institute for Cancer Genetics and the Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York. [12] Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medicine, Cornell University, New York, New York. [13] Adaptive Immunity and Lymphoma Group, German Cancer Research Center/National Center for Tumor Diseases Heidelberg, Heidelberg, Germany. [14] Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Center for Molecular Medicine, University of Cologne, Cologne, Germany.;Faculty of Medicine and University Hospital Cologne, Institute of Pathology, University of Cologne, Cologne, Germany. [15] Center for Molecular Medicine, University of Cologne, Cologne, Germany.;Cologne Excellence Cluster on Cellular Stress Response in Aging-Associated Diseases (CECAD), University of Cologne, Cologne, Germany.;Faculty of Medicine and University Hospital Cologne, Institute for Medical Microbiology, Immunology and Hygiene, University of Cologne, Cologne, Germany. [16] Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Faculty of Medicine and University Hospital Cologne, Department of Radiology and Interventional Radiology, University of Cologne, Cologne, Germany. [17] Center for Integrated Oncology, University of Cologne, Cologne, Germany.;Center for Molecular Medicine, University of Cologne, Cologne, Germany.;Department of Translational Genomics, University of Cologne, Cologne, Germany. [18] Charité Universitätsmedizin Berlin, Medical Department of Hematology, Oncology and Tumor Immunology, and Molekulares Krebsforschungszentrum - MKFZ, Virchow Campus, Berlin, Germany.;Kepler Universitätsklinikum, Medical Department of Hematology and Oncology, Johannes Kepler University, Linz, Austria. [19] Department of Hematology and Stem Cell Transplantation, University Hospital Essen, University Duisburg-Essen, German Cancer Consortium (DKTK Partner Site Essen), Essen, Germany. christian.reinhardt@uk-essen.de. [20]
DOI 10.1158/2643-3230.BCD-19-0059
PMID 33447829
发布时间 2022-03-14
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Blood cancer discovery

Blood cancer discovery

2021年2卷1期

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