OCT4 induces embryonic pluripotency via STAT3 signaling and metabolic mechanisms.

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第一作者： Giuliano G,Stirparo

第一单位： Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, United Kingdom; jn270@cam.ac.uk ggs28@cam.ac.uk.

作者： Giuliano G,Stirparo ^[1] ; Agata,Kurowski ^[2] ; Ayaka,Yanagida ^[3] ; Lawrence E,Bates ^[4] ; Stanley E,Strawbridge ^[3] ; Siarhei,Hladkou ^[2] ; Hannah T,Stuart ^[3] ; Thorsten E,Boroviak ^[5] ; Jose C R,Silva ^[3] ; Jennifer,Nichols ^[3]

作者单位： Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, United Kingdom; jn270@cam.ac.uk ggs28@cam.ac.uk. ^[1] Living Systems Institute, University of Exeter, EX4 4QD Exeter, United Kingdom. ^[2] Wellcome Trust-Medical Research Council Stem Cell Institute, Jeffrey Cheah Biomedical Centre, University of Cambridge, CB2 0AW Cambridge, United Kingdom. ^[3] Department of Pharmacological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029. ^[4] Department of Biochemistry, University of Cambridge, CB2 1GA Cambridge, United Kingdom. ^[5] Department of Physiology, Development and Neuroscience, University of Cambridge, CB2 3EG Cambridge, United Kingdom. ^[6] Centre for Trophoblast Research, University of Cambridge, CB2 3EG Cambridge, United Kingdom. ^[7]

关键词 OCT4 STAT3 pathway developmental biology metabolism single-cell profiling