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Histone demethylase JMJD3 protects against renal fibrosis by suppressing TGFβ and Notch signaling and preserving PTEN expression.

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第一作者： Chao,Yu

第一单位： Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.

作者： Chao,Yu ^[1] ; Chongxiang,Xiong ^[2] ; Jinhua,Tang ^[1] ; Xiying,Hou ^[1] ; Na,Liu ^[1] ; George,Bayliss ^[3] ; Shougang,Zhuang ^[4]

作者单位： Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China. ^[1] Department of Nephrology, the Third Affiliated Hospital of Southern Medical University, Guangzhou, 510630 China. ^[2] Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI 02903. ^[3] Department of Nephrology, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China.;Department of Medicine, Rhode Island Hospital and Alpert Medical School, Brown University, Providence, RI 02903. ^[4]

关键词 5/6 nephrectomy Jumonji domain containing-3 extracellular matrix renal fibrosis renal interstitial fibroblasts ureteral unilateral obstruction