The noradrenergic profile of plasma metanephrine in neuroblastoma patients is reproduced in xenograft mice models and arise from PNMT downregulation.

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第一作者： Karim,Abid

第一单位： Catecholamine and Peptides Laboratory, Service of Clinical Pharmacology and Toxicology, Lausanne University Hospital and University of Lausanne, Switzerland.

作者： Karim,Abid ^[1] ; Maja Beck,Popovic ^[2] ; Katia Balmas,Bourloud ^[3] ; Jacqueline,Schoumans ^[4] ; Joana,Grand-Guillaume ^[1] ; Eric,Grouzmann ^[1] ; Annick,Mühlethaler-Mottet ^[3]

作者单位： Catecholamine and Peptides Laboratory, Service of Clinical Pharmacology and Toxicology, Lausanne University Hospital and University of Lausanne, Switzerland. ^[1] Pediatric Hematology-Oncology Unit, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Switzerland. ^[2] Pediatric Hematology-Oncology Research Laboratory, Woman-Mother-Child Department, Lausanne University Hospital and University of Lausanne, Switzerland. ^[3] Oncogenomics Laboratory, Hematology Service, Laboratory Medicine and Pathology Department, Lausanne University Hospital and University of Lausanne, Switzerland. ^[4]

关键词 Phenylethanolamine N-Methyltransferase metanephrine mouse model neuroblastoma patient-derived xenograft

DOI 10.18632/oncotarget.27858

PMID 33456713

发布时间 2021-01-19

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