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Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.

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第一作者： Asad U,Malik

第一单位： Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K.

作者： Asad U,Malik ^[1] ; Athanasios,Karapetsas ^[1] ; Raja S,Nirujogi ^[1] ; Sebastian,Mathea ^[2] ; Deep,Chatterjee ^[2] ; Prosenjit,Pal ^[1] ; Pawel,Lis ^[1] ; Matthew,Taylor ^[1] ; Elena,Purlyte ^[1] ; Robert,Gourlay ^[1] ; Mark,Dorward ^[1] ; Simone,Weidlich ^[1] ; Rachel,Toth ^[1] ; Nicole K,Polinski ^[3] ; Stefan,Knapp ^[2] ; Francesca,Tonelli ^[1] ; Dario R,Alessi ^[1]

作者单位： Medical Research Council (MRC) Protein Phosphorylation and Ubiquitylation Unit, School of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, U.K. ^[1] Structural Genomics Consortium, Institute for Pharmaceutical Chemistry and Buchmann Institute for Molecular Life Sciences, Johann Wolfgang Goethe-University, Max-von-Laue-Str. 9, D-60438 Frankfurt am Main, Germany. ^[2] Michael J Fox Foundation for Parkinson's Research, Grand Central Station, PO Box 4777, New York, NY 10163, U.S.A. ^[3]

关键词 Rab GTPase kinase leucine rich repeat kinase phosphorylation