Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).-论文-万方医学网

第一作者： Zhuming,Zhang

第一单位： Janssen Research and Development, Spring House, Pennsylvania 19477, United States.

作者： Zhuming,Zhang ^[1] ; Peter J,Connolly ^[1] ; Heng Keang,Lim ^[1] ; Vineet,Pande ^[2] ; Lieven,Meerpoel ^[2] ; Christopher,Teleha ^[1] ; Jonathan R,Branch ^[1] ; Janine,Ondrus ^[1] ; Ian,Hickson ^[1] ; Tammy,Bush ^[1] ; Leopoldo,Luistro ^[1] ; Kathryn,Packman ^[3] ; James R,Bischoff ^[1] ; Salam,Ibrahim ^[1] ; Christopher,Parrett ^[4] ; Yolanda,Chong ^[2] ; Marco M,Gottardis ^[1] ; Gilles,Bignan ^[1]

作者单位： Janssen Research and Development, Spring House, Pennsylvania 19477, United States. ^[1] Janssen Research and Development, Turnhoutseweg 30, B-2340 Beerse, Belgium. ^[2] Janssen Research and Development, Cambridge, Massachusetts 02142, United States. ^[3] VWR Avantor, Spring House, Pennsylvania 19477, United States. ^[4]

主题词雄激素受体拮抗剂(Androgen Receptor Antagonists);动物(Animals);生物转化(Biotransformation);细胞系, 肿瘤(Cell Line, Tumor);狗(Dogs);药物发现(Drug Discovery);抗药性, 肿瘤(Drug Resistance, Neoplasm);肝细胞(Hepatocytes);人类(Humans);男(雄)性(Male);模型, 分子(Models, Molecular);突变(Mutation);腈类(Nitriles);甲基吡啶类(Picolines);哌啶类(Piperidines);前列腺肿瘤(Prostatic Neoplasms);吡啶类(Pyridines);大鼠(Rats);螺环化合物(Spiro Compounds);构效关系(Structure-Activity Relationship)

DOI 10.1021/acs.jmedchem.0c01563

PMID 33470111

发布时间 2021-04-26

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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).

Journal of medicinal chemistry

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Journal of medicinal chemistry

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Discovery of JNJ-63576253: A Clinical Stage Androgen Receptor Antagonist for F877L Mutant and Wild-Type Castration-Resistant Prostate Cancer (mCRPC).

Journal of medicinal chemistry

相似文献

Journal of medicinal chemistry

相关期刊

检索历史清除