Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund's adjuvant, cyclophosphamide, and polyICLC (Mel63).

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作者： Craig L,Slingluff ^[1] ; Gina R,Petroni ^[2] ; Kimberly A,Chianese-Bullock ^[2] ; Nolan A,Wages ^[3] ; Walter C,Olson ^[4] ; Kelly T,Smith ^[2] ; Kathleen,Haden ^[2] ; Lynn T,Dengel ^[3] ; Anna,Dickinson ^[4] ; Caroline,Reed ^[5] ; Elizabeth M,Gaughan ^[2] ; William W,Grosh ^[6] ; Varinder,Kaur ^[4] ; Nikole,Varhegyi ^[2] ; Mark,Smolkin ^[4] ; Nadejda V,Galeassi ^[7] ; Donna,Deacon ^[8] ; Emily H,Hall ^[8]

作者单位： Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA cls8h@virginia.edu. ^[1] University of Virginia Cancer Center, Charlottesville, Virginia, USA. ^[2] Public Health Sciences, University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[3] Department of Surgery, University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[4] Office of Research Cores Administration, University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[5] University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[6] Department of Gynecology and Obstetrics, Emory University, Atlanta, GA, USA. ^[7] Medicine, University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[8] Cardiovascular Imaging Center, University of Virginia School of Medicine, Charlottesville, Virginia, USA. ^[9]

关键词 CD4-positive T-lymphocytes adjuvants antibody formation immunogenicity immunologic melanoma vaccine

主题词投药, 口服(Administration, Oral);抗体(Antibodies);CD4阳性T淋巴细胞(CD4-Positive T-Lymphocytes);癌症疫苗(Cancer Vaccines);羧甲基纤维素钠(Carboxymethylcellulose Sodium);综合疗法(Combined Modality Therapy);环磷酰胺(Cyclophosphamide);女(雌)性(Female);Freund佐剂(Freund's Adjuvant);人类(Humans);脂类(Lipids);男(雄)性(Male);黑色素瘤(Melanoma);肿瘤分期(Neoplasm Staging);聚肌胞苷酸(Poly I-C);聚赖氨酸(Polylysine);T淋巴细胞, 调节性(T-Lymphocytes, Regulatory);治疗结果(Treatment Outcome);疫苗, 亚单位(Vaccines, Subunit)

DOI 10.1136/jitc-2020-000934

PMID 33479025

发布时间 2021-12-14

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Journal for immunotherapy of cancer

2021年9卷1期

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Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund's adjuvant, cyclophosphamide, and polyICLC (Mel63).

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

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Trial to evaluate the immunogenicity and safety of a melanoma helper peptide vaccine plus incomplete Freund's adjuvant, cyclophosphamide, and polyICLC (Mel63).

Journal for immunotherapy of cancer

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Journal for immunotherapy of cancer

相关期刊

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