作者:
Christian,Koelsche [1]
;
Daniel,Schrimpf [2]
;
Damian,Stichel [3]
;
Martin,Sill [1]
;
Felix,Sahm [2]
;
David E,Reuss [2]
;
Mirjam,Blattner [4]
;
Barbara,Worst [5]
;
Christoph E,Heilig [1]
;
Katja,Beck [2]
;
Peter,Horak [1]
;
Simon,Kreutzfeldt [2]
;
Elke,Paff [4]
;
Sebastian,Stark [6]
;
Pascal,Johann [4]
;
Florian,Selt [6]
;
Jonas,Ecker [7]
;
Dominik,Sturm [8]
;
Kristian W,Pajtler [8]
;
Annekathrin,Reinhardt [9]
;
Annika K,Wefers [8]
;
Philipp,Sievers [8]
;
Azadeh,Ebrahimi [4]
;
Abigail,Suwala [6]
;
Francisco,Fernández-Klett [7]
;
Belén,Casalini [4]
;
Andrey,Korshunov [6]
;
Volker,Hovestadt [7]
;
Felix K F,Kommoss [4]
;
Mark,Kriegsmann [6]
;
Matthias,Schick [7]
;
Melanie,Bewerunge-Hudler [4]
;
Till,Milde [7]
;
Olaf,Witt [10]
;
Andreas E,Kulozik [4]
;
Marcel,Kool [7]
;
Laura,Romero-Pérez [10]
;
Thomas G P,Grünewald [4]
;
Thomas,Kirchner [6]
;
Wolfgang,Wick [7]
;
Michael,Platten [4]
;
Andreas,Unterberg [5]
;
Matthias,Uhl [7]
;
Amir,Abdollahi [1]
;
Jürgen,Debus [2]
;
Burkhard,Lehner [1]
;
Christian,Thomas [2]
;
Martin,Hasselblatt [1]
;
Werner,Paulus [2]
;
Christian,Hartmann [2]
;
Ori,Staszewski [1]
;
Marco,Prinz [2]
;
Jürgen,Hench [1]
;
Stephan,Frank [2]
;
Yvonne M H,Versleijen-Jonkers [2]
;
Marije E,Weidema [1]
;
Thomas,Mentzel [2]
;
Klaus,Griewank [11]
;
Enrique,de Álava [12]
;
Juan Díaz,Martín [3]
;
Miguel A Idoate,Gastearena [3]
;
Kenneth Tou-En,Chang [13]
;
Sharon Yin Yee,Low [13]
;
Adrian,Cuevas-Bourdier [4]
;
Michel,Mittelbronn [7]
;
Martin,Mynarek [10]
;
Stefan,Rutkowski [4]
;
Ulrich,Schüller [7]
;
Viktor F,Mautner [10]
;
Jens,Schittenhelm [4]
;
Jonathan,Serrano [7]
;
Matija,Snuderl [4]
;
Reinhard,Büttner [5]
;
Thomas,Klingebiel [14]
;
Rolf,Buslei [14]
;
Manfred,Gessler [15]
;
Pieter,Wesseling [16]
;
Winand N M,Dinjens [17]
;
Sebastian,Brandner [18]
;
Zane,Jaunmuktane [19]
;
Iben,Lyskjær [20]
;
Peter,Schirmacher [21]
;
Albrecht,Stenzinger [22]
;
Benedikt,Brors [21]
;
Hanno,Glimm [22]
;
Christoph,Heining [23]
;
Oscar M,Tirado [24]
;
Miguel,Sáinz-Jaspeado [21]
;
Jaume,Mora [22]
;
Javier,Alonso [23]
;
Xavier Garcia,Del Muro [24]
;
Sebastian,Moran [25]
;
Manel,Esteller [26]
;
Jamal K,Benhamida [26]
;
Marc,Ladanyi [26]
;
Eva,Wardelmann [27]
;
Cristina,Antonescu [28]
;
Adrienne,Flanagan [29]
;
Uta,Dirksen [28]
;
Peter,Hohenberger [30]
;
Daniel,Baumhoer [31]
;
Wolfgang,Hartmann [32]
;
Christian,Vokuhl [32]
;
Uta,Flucke [33]
;
Iver,Petersen [33]
;
Gunhild,Mechtersheimer [34]
;
David,Capper [35]
;
David T W,Jones [36]
;
Stefan,Fröhling [37]
;
Stefan M,Pfister [36]
;
Andreas,von Deimling [38]
作者单位:
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
[1]
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[2]
Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany.
[3]
Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany.
[4]
Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[5]
Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[6]
Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany.
[7]
Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany.
[8]
Heidelberg Center for Personalized Oncology (HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[9]
Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[10]
Broad Institute of MIT and Harvard, Cambridge, MA, USA.
[11]
Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
[12]
Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[13]
Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
[14]
Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany.
[15]
Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany.
[16]
Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[17]
Department of Neurology, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
[18]
Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[19]
Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany.
[20]
Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany.
[21]
Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany.
[22]
Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany.
[23]
Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[24]
Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany.
[25]
Institute of Neuropathology, University Hospital Münster, Münster, Germany.
[26]
Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany.
[27]
Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[28]
Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[29]
Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany.
[30]
Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany.
[31]
Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland.
[32]
Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands.
[33]
Dermatopathology Bodensee, Friedrichshafen, Germany.
[34]
Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany.
[35]
Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC, Seville, Spain.
[36]
Department of Normal and Pathological Cytology and Histology, School of Medicine. University of Seville, Seville, Spain.
[37]
Department of Pathological Anatomy, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain.
[38]
Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore.
[39]
Department of Neurosurgery, National Neuroscience Institute, Singapore, Republic of Singapore.
[40]
National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg.
[41]
Luxembourg Center of Neuropathology (LCNP), Luxembourg, Luxembourg.
[42]
Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg.
[43]
Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg.
[44]
Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[45]
Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[46]
Research Institute Children's Cancer Center Hamburg, Hamburg, Germany.
[47]
Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
[48]
Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany.
[49]
Department of Pathology, New York University School of Medicine, New York, NY, USA.
[50]
Institute of Pathology, Cologne University Hospital, Cologne, Germany.
[51]
Department of Pediatric Hematology and Oncology, University Children's Hospital, Frankfurt/Main, Germany.
[52]
Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany.
[53]
Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Würzburg University, Würzburg, Germany.
[54]
Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands.
[55]
Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands.
[56]
Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
[57]
Department of Neurodegeneration, Institute of Neurology, University College London, London, UK.
[58]
Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK.
[59]
Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK.
[60]
Research Department of Pathology, University College London, London, UK.
[61]
Division of Applied Bioinformatics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
[62]
Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany.
[63]
Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Dresden, Germany.
[64]
Center for Personalized Oncology, National Center for Tumor Diseases (NCT) Dresden and University Hospital Carl Gustav Carus Dresden at TU Dresden, Dresden, Germany.
[65]
German Cancer Consortium (DKTK), Dresden, Germany.
[66]
Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC, Barcelona, Catalonia, Spain.
[67]
Department of Pediatric Onco-Hematology and Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain.
[68]
Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III (ISCIII), Madrid, Spain.
[69]
Medical Oncology Service, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, Barcelona, Catalonia, Spain.
[70]
Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain.
[71]
Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain.
[72]
Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain.
[73]
Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain.
[74]
Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain.
[75]
Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
[76]
Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
[77]
Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK.
[78]
University College London Cancer Institute, London, UK.
[79]
Pediatrics III Pediatric Hematology, Oncology, Immunology, Cardiology, Pulmonology, West German Cancer Center, University Hospital Essen, Essen, Germany.
[80]
International Ewing Sarcoma Study Group, German Cancer Consortium (DKTK), West German Cancer Center (WTZ), University Duisburg-Essen, Essen, Germany.
[81]
Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany.
[82]
Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland.
[83]
Division of Translational Pathology, Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany.
[84]
Department of Pediatric Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany.
[85]
Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands.
[86]
Institute of Pathology, SRH Poliklinik Gera GmbH, Gera, Germany.
[87]
Institute of Pathology, Jena University Hospital, Jena, Germany.
[88]
Department of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany.
[89]
Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de.
[90]
Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de.
[91]
主题词
算法(Algorithms);骨肿瘤(Bone Neoplasms);队列研究(Cohort Studies);DNA拷贝数变异(DNA Copy Number Variations);DNA甲基化(DNA Methylation);人类(Humans);因特网(Internet);结果可重复性(Reproducibility of Results);肉瘤(Sarcoma);敏感性与特异性(Sensitivity and Specificity);软组织肿瘤(Soft Tissue Neoplasms)
DOI
10.1038/s41467-020-20603-4
PMID
33479225
发布时间
2022-07-16
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