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Sarcoma classification by DNA methylation profiling.

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作者: Christian,Koelsche [1] ; Daniel,Schrimpf [2] ; Damian,Stichel [3] ; Martin,Sill [1] ; Felix,Sahm [2] ; David E,Reuss [2] ; Mirjam,Blattner [4] ; Barbara,Worst [5] ; Christoph E,Heilig [1] ; Katja,Beck [2] ; Peter,Horak [1] ; Simon,Kreutzfeldt [2] ; Elke,Paff [4] ; Sebastian,Stark [6] ; Pascal,Johann [4] ; Florian,Selt [6] ; Jonas,Ecker [7] ; Dominik,Sturm [8] ; Kristian W,Pajtler [8] ; Annekathrin,Reinhardt [9] ; Annika K,Wefers [8] ; Philipp,Sievers [8] ; Azadeh,Ebrahimi [4] ; Abigail,Suwala [6] ; Francisco,Fernández-Klett [7] ; Belén,Casalini [4] ; Andrey,Korshunov [6] ; Volker,Hovestadt [7] ; Felix K F,Kommoss [4] ; Mark,Kriegsmann [6] ; Matthias,Schick [7] ; Melanie,Bewerunge-Hudler [4] ; Till,Milde [7] ; Olaf,Witt [10] ; Andreas E,Kulozik [4] ; Marcel,Kool [7] ; Laura,Romero-Pérez [10] ; Thomas G P,Grünewald [4] ; Thomas,Kirchner [6] ; Wolfgang,Wick [7] ; Michael,Platten [4] ; Andreas,Unterberg [5] ; Matthias,Uhl [7] ; Amir,Abdollahi [1] ; Jürgen,Debus [2] ; Burkhard,Lehner [1] ; Christian,Thomas [2] ; Martin,Hasselblatt [1] ; Werner,Paulus [2] ; Christian,Hartmann [2] ; Ori,Staszewski [1] ; Marco,Prinz [2] ; Jürgen,Hench [1] ; Stephan,Frank [2] ; Yvonne M H,Versleijen-Jonkers [2] ; Marije E,Weidema [1] ; Thomas,Mentzel [2] ; Klaus,Griewank [11] ; Enrique,de Álava [12] ; Juan Díaz,Martín [3] ; Miguel A Idoate,Gastearena [3] ; Kenneth Tou-En,Chang [13] ; Sharon Yin Yee,Low [13] ; Adrian,Cuevas-Bourdier [4] ; Michel,Mittelbronn [7] ; Martin,Mynarek [10] ; Stefan,Rutkowski [4] ; Ulrich,Schüller [7] ; Viktor F,Mautner [10] ; Jens,Schittenhelm [4] ; Jonathan,Serrano [7] ; Matija,Snuderl [4] ; Reinhard,Büttner [5] ; Thomas,Klingebiel [14] ; Rolf,Buslei [14] ; Manfred,Gessler [15] ; Pieter,Wesseling [16] ; Winand N M,Dinjens [17] ; Sebastian,Brandner [18] ; Zane,Jaunmuktane [19] ; Iben,Lyskjær [20] ; Peter,Schirmacher [21] ; Albrecht,Stenzinger [22] ; Benedikt,Brors [21] ; Hanno,Glimm [22] ; Christoph,Heining [23] ; Oscar M,Tirado [24] ; Miguel,Sáinz-Jaspeado [21] ; Jaume,Mora [22] ; Javier,Alonso [23] ; Xavier Garcia,Del Muro [24] ; Sebastian,Moran [25] ; Manel,Esteller [26] ; Jamal K,Benhamida [26] ; Marc,Ladanyi [26] ; Eva,Wardelmann [27] ; Cristina,Antonescu [28] ; Adrienne,Flanagan [29] ; Uta,Dirksen [28] ; Peter,Hohenberger [30] ; Daniel,Baumhoer [31] ; Wolfgang,Hartmann [32] ; Christian,Vokuhl [32] ; Uta,Flucke [33] ; Iver,Petersen [33] ; Gunhild,Mechtersheimer [34] ; David,Capper [35] ; David T W,Jones [36] ; Stefan,Fröhling [37] ; Stefan M,Pfister [36] ; Andreas,von Deimling [38]
作者单位: Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. [1] Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [2] Department of General Pathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. [3] Hopp Children's Cancer Center Heidelberg (KiTZ), Heidelberg, Germany. [4] Division of Pediatric Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [5] Pediatric Glioma Research Group, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [6] Department of Pediatric Oncology, Hematology and Immunology, Heidelberg University Hospital, Heidelberg, Germany. [7] Division of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Heidelberg and German Cancer Research Center (DKFZ), German Cancer Consortium (DKTK), Heidelberg, Germany. [8] Heidelberg Center for Personalized Oncology (HIPO), German Cancer Research Center (DKFZ), Heidelberg, Germany. [9] Clinical Cooperation Unit Pediatric Oncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [10] Broad Institute of MIT and Harvard, Cambridge, MA, USA. [11] Department of Pathology and Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. [12] Genomics and Proteomics Core Facility, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [13] Max-Eder Research Group for Pediatric Sarcoma Biology, Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. [14] Institute of Pathology, Faculty of Medicine, LMU Munich, Munich, Germany. [15] Neurology Clinic and National Center for Tumor Diseases, University Hospital Heidelberg, Heidelberg, Germany. [16] Clinical Cooperation Unit Neurooncology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [17] Department of Neurology, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany. [18] Clinical Cooperation Unit Neuroimmunology and Brain Tumor Immunology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [19] Department of Neurosurgery, Heidelberg University Hospital, Heidelberg, Germany. [20] Department of Radiation Oncology, Heidelberg University Hospital, Heidelberg, Germany. [21] Heidelberg Institute of Radiation Oncology (HIRO), National Center for Radiation Research in Oncology (NCRO), Heidelberg, Germany. [22] Heidelberg Ion-Beam Therapy Center (HIT), Heidelberg, Germany. [23] Translational Radiation Oncology, German Cancer Consortium (DKTK), National Center for Tumor Diseases (NCT), German Cancer Research Center (DKFZ), Heidelberg, Germany. [24] Department of Orthopaedics, Trauma Surgery and Paraplegiology, Heidelberg University Hospital, Heidelberg, Germany. [25] Institute of Neuropathology, University Hospital Münster, Münster, Germany. [26] Department of Neuropathology, Institute of Pathology, Hannover Medical School (MHH), Hannover, Germany. [27] Institute of Neuropathology, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [28] Berta-Ottenstein-Programme for Clinician Scientists, Faculty of Medicine, University of Freiburg, Freiburg, Germany. [29] Signalling Research Centers BIOSS and CIBSS, University of Freiburg, Freiburg, Germany. [30] Center for Basics in NeuroModulation (NeuroModulBasics), Faculty of Medicine, University of Freiburg, Freiburg, Germany. [31] Department of Neuropathology, Institute of Pathology, Basel University Hospital, Basel, Switzerland. [32] Department of Medical Oncology, Radboud University Medical Center, Nijmegen, The Netherlands. [33] Dermatopathology Bodensee, Friedrichshafen, Germany. [34] Department of Dermatology, University Hospital Essen, West German Cancer Center, University Duisburg-Essen, Essen, Germany. [35] Department of Pathology, Institute of Biomedicine of Sevilla (IBiS), Virgen del Rocio University Hospital, CSIC/University of Sevilla/CIBERONC, Seville, Spain. [36] Department of Normal and Pathological Cytology and Histology, School of Medicine. University of Seville, Seville, Spain. [37] Department of Pathological Anatomy, Clínica Universidad de Navarra, University of Navarra, Pamplona, Spain. [38] Department of Pathology and Laboratory Medicine, KK Women's and Children's Hospital, Singapore, Republic of Singapore. [39] Department of Neurosurgery, National Neuroscience Institute, Singapore, Republic of Singapore. [40] National Center of Pathology (NCP), Laboratoire National de Santé (LNS), Dudelange, Luxembourg. [41] Luxembourg Center of Neuropathology (LCNP), Luxembourg, Luxembourg. [42] Luxembourg Centre for Systems Biomedicine (LCSB), University of Luxembourg, Luxembourg, Luxembourg. [43] Department of Oncology (DONC), Luxembourg Institute of Health (LIH), Luxembourg, Luxembourg. [44] Department of Pediatric Hematology and Oncology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [45] Institute of Neuropathology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [46] Research Institute Children's Cancer Center Hamburg, Hamburg, Germany. [47] Department of Neurology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany. [48] Department of Neuropathology, Institute of Pathology and Neuropathology, University Hospital of Tübingen, Tübingen, Germany. [49] Department of Pathology, New York University School of Medicine, New York, NY, USA. [50] Institute of Pathology, Cologne University Hospital, Cologne, Germany. [51] Department of Pediatric Hematology and Oncology, University Children's Hospital, Frankfurt/Main, Germany. [52] Institute of Pathology, Sozialstiftung Bamberg, Klinikum am Bruderwald, Bamberg, Germany. [53] Theodor-Boveri-Institute/Biocenter, Developmental Biochemistry, Würzburg University, Würzburg, Germany. [54] Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. [55] Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands. [56] Department of Pathology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. [57] Department of Neurodegeneration, Institute of Neurology, University College London, London, UK. [58] Division of Neuropathology, The National Hospital for Neurology and Neurosurgery, University College London Hospitals NHS Foundation Trust, London, UK. [59] Department of Molecular Neuroscience, UCL Queen Square Institute of Neurology, University College London, London, UK. [60] Research Department of Pathology, University College London, London, UK. [61] Division of Applied Bioinformatics, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. [62] Translational and Functional Cancer Genomics, National Center for Tumor Diseases (NCT) and German Cancer Research Center (DKFZ), Heidelberg, Germany. [63] Department of Translational Medical Oncology, National Center for Tumor Diseases (NCT) Dresden and German Cancer Research Center (DKFZ), Dresden, Germany. [64] Center for Personalized Oncology, National Center for Tumor Diseases (NCT) Dresden and University Hospital Carl Gustav Carus Dresden at TU Dresden, Dresden, Germany. [65] German Cancer Consortium (DKTK), Dresden, Germany. [66] Sarcoma Research Group, Oncobell Program, Bellvitge Biomedical Research Institute (IDIBELL), CIBERONC, Barcelona, Catalonia, Spain. [67] Department of Pediatric Onco-Hematology and Developmental Tumor Biology Laboratory, Hospital Sant Joan de Déu, Barcelona, Catalonia, Spain. [68] Pediatric Solid Tumor Laboratory, Human Genetic Department, Research Institute of Rare Diseases, Instituto de Salud Carlos III (ISCIII), Madrid, Spain. [69] Medical Oncology Service, Catalan Institute of Oncology (ICO), Bellvitge Biomedical Research Institute (IDIBELL), University of Barcelona, Barcelona, Catalonia, Spain. [70] Cancer Epigenetics and Biology Program (PEBC), Bellvitge Biomedical Research Institute (IDIBELL), Barcelona, Catalonia, Spain. [71] Josep Carreras Leukaemia Research Institute (IJC), Badalona, Barcelona, Catalonia, Spain. [72] Centro de Investigacion Biomedica en Red Cancer (CIBERONC), Madrid, Spain. [73] Institucio Catalana de Recerca i Estudis Avançats (ICREA), Barcelona, Catalonia, Spain. [74] Physiological Sciences Department, School of Medicine and Health Sciences, University of Barcelona (UB), Barcelona, Catalonia, Spain. [75] Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. [76] Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany. [77] Department of Histopathology, Royal National Orthopaedic Hospital NHS Trust, Stanmore, Middlesex, UK. [78] University College London Cancer Institute, London, UK. [79] Pediatrics III Pediatric Hematology, Oncology, Immunology, Cardiology, Pulmonology, West German Cancer Center, University Hospital Essen, Essen, Germany. [80] International Ewing Sarcoma Study Group, German Cancer Consortium (DKTK), West German Cancer Center (WTZ), University Duisburg-Essen, Essen, Germany. [81] Division of Surgical Oncology and Thoracic Surgery, Mannheim University Medical Center, University of Heidelberg, Mannheim, Germany. [82] Bone Tumour Reference Centre at the Institute of Pathology, University Hospital Basel and University of Basel, Basel, Switzerland. [83] Division of Translational Pathology, Gerhard Domagk Institute of Pathology, University Hospital Münster, Münster, Germany. [84] Department of Pediatric Pathology, University Hospital of Schleswig-Holstein, Kiel, Germany. [85] Department of Pathology, Radboud University Medical Center, Nijmegen, The Netherlands. [86] Institute of Pathology, SRH Poliklinik Gera GmbH, Gera, Germany. [87] Institute of Pathology, Jena University Hospital, Jena, Germany. [88] Department of Neuropathology, Charité Universitätsmedizin Berlin, Berlin, Germany. [89] Department of Neuropathology, Institute of Pathology, Heidelberg University Hospital, Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de. [90] Clinical Cooperation Unit Neuropathology, German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany. andreas.vondeimling@med.uni-heidelberg.de. [91]
DOI 10.1038/s41467-020-20603-4
PMID 33479225
发布时间 2022-07-16
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