Negative allosteric modulators of cannabinoid receptor 1: Ternary complexes including CB1, orthosteric CP55940 and allosteric ORG27569.

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作者： AyoOluwa O,Aderibigbe ^[1] ; Pankaj,Pandey ^[1] ; Robert J,Doerksen ^[2]

作者单位： Department of BioMolecular Sciences, Division of Medicinal Chemistry, School of Pharmacy, University of Mississippi, University, MS, USA. ^[1] National Center for Natural Products Research, University of Mississippi, University, Mississippi, USA. ^[2] Research Institute of Pharmaceutical Sciences, School of Pharmacy, University of Mississippi, University, MS, USA. ^[3]

关键词 CP55940 Cannabinoid receptor 1 ORG27569 allosteric modulator molecular docking orthosteric site

主题词别构调节(Allosteric Regulation);别构部位(Allosteric Site);环己醇类(Cyclohexanols);吲哚类(Indoles);哌啶类(Piperidines);蛋白质结合(Protein Binding);受体, 大麻酚(Receptors, Cannabinoid)

DOI 10.1080/07391102.2021.1873187

PMID 33480332

发布时间 2022-08-30

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