Effect of early sleep apnoea treatment with adaptive servo-ventilation in acute stroke patients on cerebral lesion evolution and neurological outcomes: study protocol for a multicentre, randomized controlled, rater-blinded, clinical trial (eSATIS: early Sleep Apnoea Treatment in Stroke).

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第一作者： Simone B,Duss

第一单位： Department of Neurology, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland.

作者： Simone B,Duss ^[1] ; Anne-Kathrin,Brill ^[2] ; Sébastien,Baillieul ^[2] ; Thomas,Horvath ^[3] ; Frédéric,Zubler ^[4] ; Dominique,Flügel ^[5] ; Georg,Kägi ^[1] ; Gabriel,Benz ^[1] ; Corrado,Bernasconi ^[6] ; Sebastian R,Ott ^[6] ; Lyudmila,Korostovtseva ^[7] ; Yurii,Sviryaev ^[1] ; Farid,Salih ^[3] ; Matthias,Endres ^[8] ; Renaud,Tamisier ^[8] ; Haralampos,Gouveris ^[9] ; Yaroslav,Winter ^[9] ; Niklaus,Denier ^[4] ; Roland,Wiest ^[5] ; Marcel,Arnold ^[10] ; Markus H,Schmidt ^[11] ; Jean-Louis,Pépin ^[12] ; Claudio L A,Bassetti ^[12]

作者单位： Department of Neurology, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. ^[1] Interdisciplinary Sleep-Wake-Epilepsy-Center, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. ^[2] Department of Pulmonary Medicine, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. ^[3] Grenoble Alpes University, HP2 Laboratory, INSERM U1042, Grenoble, France. ^[4] Pôle Thorax et Vaisseaux, Grenoble Alpes University Hospital, Grenoble, France. ^[5] Department of Neurology, Cantonal Hospital St. Gallen, St. Gallen, Switzerland. ^[6] Department of Pneumology, Cantonal Hospital St Gallen, St. Gallen, Switzerland. ^[7] Hypertension Department, Somnology Group, Almazov National Medical Research Centre, St. Petersburg, Russia. ^[8] Department of Neurology, Center for Stroke Research Berlin (CSB), Charité - University Medicine Berlin, Berlin, Germany. ^[9] Department of Otorhinolaryngology, Medical Centre of the Johannes Gutenberg University, Mainz, Germany. ^[10] Department of Neurology, Medical Centre of the Johannes Gutenberg University, Mainz, Germany. ^[11] University Institute of Diagnostic and Interventional Neuroradiology, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. ^[12] Department of Neurology, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. Claudio.Bassetti@insel.ch. ^[13] Interdisciplinary Sleep-Wake-Epilepsy-Center, Bern University Hospital (Inselspital) and University of Bern, Bern, Switzerland. Claudio.Bassetti@insel.ch. ^[14] Department of Neurology, Sechenov University, Moscow, Russia. Claudio.Bassetti@insel.ch. ^[15]

关键词 Adaptive servo-ventilation MRI evolution Outcome Randomized controlled trial Sleep-disordered breathing Stroke Treatment