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Smad4 deficiency substitutes Cdkn2b but not Cdkn2a downregulation in pancreatic cancer following induction of genetic events in adult mice.

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作者: Xintong,Jia [1] ; Bin,Sun [2] ; Qiu,Tu [3] ; Huaxin,Qi [4] ; Lin,Li [5] ; Xiuyun,Liu [4] ; Lanzhen,Yan [2] ; Hongjuan,Dai [4] ; Qingpeng,Kong [6] ; Chengwei,Tang [7] ; Xudong,Zhao [8]
作者单位: Laboratory of Gastroenterology & Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China; State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. [1] Laboratory of Animal Tumor Models/Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. [2] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Central Laboratory of Yan'an Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. [3] Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. [4] Key Laboratory of Tumor Immunological Prevention and Treatment of Yunnan Province, Central Laboratory of Yan'an Hospital, Affiliated to Kunming Medical University, Kunming, Yunnan, China. [5] State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China. [6] Laboratory of Gastroenterology & Hepatology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Department of Gastroenterology, West China Hospital, Sichuan University, Chengdu, China. Electronic address: shcqcdmed@163.com. [7] Laboratory of Animal Tumor Models/Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan, China; Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences/Key Laboratory of Bioactive Peptides of Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; KIZ-SU Joint Laboratory of Animal Model and Drug Development, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, China. Electronic address: zhaoxudong@wchscu.cn. [8]
DOI 10.1016/j.pan.2021.01.004
PMID 33483239
发布时间 2024-02-26
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Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]

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