A two-site flexible clamp mechanism for RET-GDNF-GFRα1 assembly reveals both conformational adaptation and strict geometric spacing.

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作者： Sarah E,Adams ^[1] ; Andrew G,Purkiss ^[2] ; Phillip P,Knowles ^[1] ; Andrea,Nans ^[2] ; David C,Briggs ^[1] ; Annabel,Borg ^[2] ; Christopher P,Earl ^[1] ; Kerry M,Goodman ^[1] ; Agata,Nawrotek ^[1] ; Aaron J,Borg ^[3] ; Pauline B,McIntosh ^[4] ; Francesca M,Houghton ^[1] ; Svend,Kjær ^[2] ; Neil Q,McDonald ^[5]

作者单位： Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT London, UK. ^[1] Structural Biology Science Technology Platform, Francis Crick Institute, NW1 1AT London, UK. ^[2] Mass Spectrometry Science Technology Platform, Francis Crick Institute, NW1 1AT London, UK. ^[3] Structural Biology of Cells and Viruses Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK. ^[4] Signalling and Structural Biology Laboratory, Francis Crick Institute, NW1 1AT London, UK; Institute of Structural and Molecular Biology, Department of Biological Sciences, Birkbeck College, Malet Street, London WC1E 7HX, UK. Electronic address: neil.mcdonald@crick.ac.uk. ^[5]

关键词 GDNF family ligands RET X-ray crystallography co-receptor cryo-EM cystine knot glycosylation ligand recognition receptor tyrosine kinase