Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation.

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作者： Chi,Ma ^[1] ; FuKun W,Hoffmann ^[1] ; Michael P,Marciel ^[1] ; Kathleen E,Page ^[2] ; Melodie A,Williams-Aduja ^[2] ; Ellis N L,Akana ^[2] ; Greg S,Gojanovich ^[1] ; Mariana,Gerschenson ^[1] ; Johann,Urschitz ^[3] ; Stefan,Moisyadi ^[3] ; Vedbar S,Khadka ^[4] ; Sharon,Rozovsky ^[5] ; Youping,Deng ^[4] ; F David,Horgen ^[2] ; Peter R,Hoffmann ^[6]

作者单位： Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. ^[1] Department of Natural Sciences, Hawaii Pacific University, Kaneohe, HI 96744, USA. ^[2] Department of Anatomy, Physiology and Biochemistry, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. ^[3] Department of Quantitative Health Sciences, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. ^[4] Department of Chemistry and Biochemistry, University of Delaware, Newark, DE 19716, USA. ^[5] Department of Cell and Molecular Biology, John A. Burns School of Medicine, University of Hawaii, Honolulu, HI 96813, USA. Electronic address: peterrh@hawaii.edu. ^[6]

关键词 AMPK Ethanolamine phosphotransferase Glycolysis Metabolic sensing Phosphatidylethanolamine Selenium Selenoprotein

主题词动物(Animals);细胞增殖(Cell Proliferation);乙醇胺(Ethanolamine);乙醇胺类(Ethanolamines);女(雌)性(Female);糖酵解(Glycolysis);糖基磷脂酰肌醇类(Glycosylphosphatidylinositols);脂肪生成(Lipogenesis);男(雄)性(Male);代谢网络和途径(Metabolic Networks and Pathways);代谢组学(Metabolomics);小鼠(Mice);小鼠, 基因敲除(Mice, Knockout);磷脂酰乙醇胺类(Phosphatidylethanolamines);磷脂类(Phospholipids);硒蛋白质类(Selenoproteins);T淋巴细胞(T-Lymphocytes)

DOI 10.1016/j.molmet.2021.101170

PMID 33484950

发布时间 2022-01-13

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Molecular metabolism

2021年47卷

101170页

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Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation.

Molecular metabolism

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Molecular metabolism

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Upregulated ethanolamine phospholipid synthesis via selenoprotein I is required for effective metabolic reprogramming during T cell activation.

Molecular metabolism

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Molecular metabolism

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