首页> Journal of clinical immunology> Infectious Complications Predict Premature CD8<sup>+</sup> T-cell Senescence in CD40 Ligand-Deficient Patients.

Infectious Complications Predict Premature CD8<sup>+</sup> T-cell Senescence in CD40 Ligand-Deficient Patients.

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第一作者： Junghee J,Shin

第一单位： Section of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.

作者： Junghee J,Shin ^[1] ; Jason,Catanzaro ^[2] ; Jennifer R,Yonkof ^[3] ; Ottavia,Delmonte ^[4] ; Keith,Sacco ^[4] ; Min Sun,Shin ^[1] ; Srikar,Reddy ^[1] ; Paula J,Whittington ^[5] ; Gary,Soffer ^[2] ; Peter J,Mustillo ^[3] ; Kathleen E,Sullivan ^[6] ; Luigi D,Notarangelo ^[4] ; Roshini S,Abraham ^[7] ; Neil,Romberg ^[6] ; Insoo,Kang ^[8]

作者单位： Section of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. ^[1] Section of Pulmonology, Allergy, Immunology and Sleep Medicine, Department of Pediatrics, Yale University School of Medicine, New Haven, CT, 06520, USA. ^[2] Division of Allergy and Immunology, Nationwide Children's Hospital, Columbus, OH, 43212, USA. ^[3] Laboratory of Clinical Immunology and Microbiology, National Institution of Allergy and Infectious Diseases, NIH, Bethesda, MD, 20893, USA. ^[4] Section of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA.;Department of Allergy and Immunology, Mid-Atlantic Permanente Medical Group of Kaiser Permanente, Rockville, MD, 20852, USA. ^[5] Division of Allergy and Immunology, The Children's Hospital of Philadelphia, Philadelphia, PA, 19104, USA.;Department of Pediatrics, The Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. ^[6] Division of Allergy and Immunology, Nationwide Children's Hospital, Columbus, OH, 43212, USA.;Department of Pathology and Laboratory Medicine, Nationwide Children's Hospital, Columbus, OH, 43212, USA. ^[7] Section of Rheumatology, Allergy and Immunology, Departments of Internal Medicine, Yale University School of Medicine, New Haven, CT, 06520, USA. Insoo.kang@yale.edu. ^[8]

关键词 CD8+ T-cell senescence Pneumocystis jirovecii pneumonia (PJP) prophylactic antibiotics X-linked CD40 ligand deficiency class switching recombination defect combined immunodeficiency immunoglobulin replacement therapy