Hypoxia promotes the metastasis of pancreatic cancer through regulating NOX4/KDM5A-mediated histone methylation modification changes in a HIF1A-independent manner.

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作者： Hongzhen,Li ^[1] ; Chunyan,Peng ^[1] ; Chenhui,Zhu ^[2] ; Shuang,Nie ^[1] ; Xuetian,Qian ^[2] ; Zhao,Shi ^[2] ; Mengyue,Shi ^[1] ; Yan,Liang ^[3] ; Xiwei,Ding ^[1] ; Shu,Zhang ^[1] ; Bin,Zhang ^[1] ; Xihan,Li ^[1] ; Guifang,Xu ^[1] ; Ying,Lv ^[1] ; Lei,Wang ^[1] ; Helmut,Friess ^[4] ; Bo,Kong ^[1] ; Xiaoping,Zou ^[4] ; Shanshan,Shen ^[5]

作者单位： Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China. ^[1] Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China. ^[2] Department of Pathology, East Region Military Command General Hospital, Nanjing, Jiangsu, China. ^[3] Department of Surgery, Klinikum Rechts Der Isar, School of Medicine, Technical University of Munich (TUM), Munich, Germany. ^[4] Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China. zouxp@nju.edu.cn. ^[5] Department of Gastroenterology, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China. zouxp@nju.edu.cn. ^[6] Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, No. 321 Zhongshan Road, Nanjing, 210008, Jiangsu, China. shenshanshan@njglyy.com. ^[7]

关键词 Epithelial-to-mesenchymal transition Histone methylation modification Hypoxia NOX4 SNAIL1