Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.-论文-万方医学网

作者： Nelson E,Bruno ^[1] ; Jerome C,Nwachukwu ^[1] ; Sathish,Srinivasan ^[1] ; Charles C,Nettles ^[1] ; Tina,Izard ^[1] ; Zhuang,Jin ^[2] ; Jason,Nowak ^[3] ; Michael D,Cameron ^[1] ; Siddaraju V,Boregowda ^[2] ; Donald G,Phinney ^[2] ; Olivier,Elemento ^[2] ; Xu,Liu ^[4] ; Eric A,Ortlund ^[5] ; René,Houtman ^[5] ; Diana A,Stavreva ^[6] ; Gordon L,Hager ^[7] ; Theodore M,Kamenecka ^[7] ; Douglas J,Kojetin ^[2] ; Kendall W,Nettles ^[1]

作者单位： Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL, USA. ^[1] Department of Molecular Medicine, The Scripps Research Institute, Jupiter, FL, USA. ^[2] Corbus Pharmaceuticals, Inc., Norwood, MA, USA. ^[3] Caryl and Israel Englander Institute for Precision Medicine, Institute for Computational Biomedicine, Department of Physiology and Biophysics, Weill Cornell Medicine, New York, NY, USA. ^[4] Department of Biochemistry, Emory University School of Medicine, Atlanta, GA, USA. ^[5] Department of Research and Development, PamGene, 's-Hertogenbosch, the Netherlands. ^[6] Laboratory of Receptor Biology and Gene Expression, National Cancer Institute, Bethesda, MD, USA. ^[7] Department of Integrative Structural and Computational Biology, The Scripps Research Institute, Jupiter, FL, USA. knettles@scripps.edu. ^[8]

主题词别构调节(Allosteric Regulation);动物(Animals);消炎药(Anti-Inflammatory Agents);细胞系, 转化(Cell Line, Transformed);基因表达调控(Gene Expression Regulation);葡萄糖(Glucose);葡萄糖转运体4型(Glucose Transporter Type 4);人类(Humans);脂多糖类(Lipopolysaccharides);男(雄)性(Male);膜电位, 线粒体(Membrane Potential, Mitochondrial);小鼠(Mice);小鼠, 近交C57BL(Mice, Inbred C57BL);线粒体(Mitochondria);肌纤维, 骨骼(Muscle Fibers, Skeletal);肌萎缩(Muscular Atrophy);成肌细胞(Myoblasts);大鼠(Rats);受体, 糖皮质激素(Receptors, Glucocorticoid);信号传导(Signal Transduction);构效关系(Structure-Activity Relationship)

DOI 10.1038/s41589-020-00719-w

PMID 33510451

发布时间 2023-01-28

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Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.

Nature chemical biology

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Nature chemical biology

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Chemical systems biology reveals mechanisms of glucocorticoid receptor signaling.

Nature chemical biology

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Nature chemical biology

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