Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.

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作者： Weiqiang,Chen ^[1] ; Suan-Sin,Foo ^[1] ; Eunjin,Hong ^[2] ; Christine,Wu ^[2] ; Wai-Suet,Lee ^[2] ; Shin-Ae,Lee ^[1] ; Denis,Evseenko ^[2] ; Maria Elisabeth Lopes,Moreira ^[3] ; Adolfo,García-Sastre ^[4] ; Genhong,Cheng ^[5] ; Karin,Nielsen-Saines ^[6] ; Patrícia,Brasil ^[7] ; Elyzabeth,Avvad-Portari ^[8] ; Jae U,Jung ^[9]

作者单位： Department of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. ^[1] Keck School of Medicine, University of Southern California, Los Angeles, CA, USA. ^[2] Clinical Research Unit, Fernandes Figueira Institute-FioCruz, Flamengo, Rio De Janeiro, Brazil. ^[3] Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[4] Department of Medicine, Division of Infectious Diseases, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[5] Global Health and Emerging Pathogens Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[6] The Tisch Cancer Institute, Icahn School of Medicine at Mount Sinai, New York, NY, USA. ^[7] Department of Microbiology and Molecular Genetics, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[8] Division of Pediatric Infectious Diseases, David Geffen School of Medicine, University of California, Los Angeles, Los Angeles, CA, USA. ^[9] Laboratório de Pesquisa Clínica em Doenças Febris Agudas, Instituto Nacional de Infectologia Evandro Chagas, FioCruz, Rio de Janeiro, Brazil. ^[10] Department of Pathology, Fernandes Figueira Institute-FioCruz, Rio De Janeiro, Brazil. ^[11] Department of Cancer Biology and Global Center for Pathogens Research and Human Health, Lerner Research Institute, Cleveland Clinic, Cleveland, OH, USA. jungj@ccf.org. ^[12]

主题词动物(Animals);骨形态发生蛋白质2(Bone Morphogenetic Protein 2);骨形态发生蛋白质类(Bone Morphogenetic Proteins);脑(Brain);钙质沉着症(Calcinosis);钙(Calcium);细胞, 培养的(Cells, Cultured);胎儿(Fetus);人类(Humans);传染性疾病传播, 垂直(Infectious Disease Transmission, Vertical);小鼠(Mice);小鼠, 转基因(Mice, Transgenic);骨生成(Osteogenesis);周细胞(Pericytes);STAT2转录因子(STAT2 Transcription Factor);丝氨酸内肽酶类(Serine Endopeptidases);信号传导(Signal Transduction);病毒蛋白质类(Viral Proteins)

DOI 10.1038/s41564-020-00850-3

PMID 33510473

发布时间 2023-03-04

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Nature microbiology

2021年6卷4期

455-466页

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Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.

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Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses.

Nature microbiology

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