换一批
换一批Gut microbiome mediates host genomic effects on phenotypes: a case study with fat deposition in pigs.
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关键词
BEL, Weight of the belly cutBF1, Backfat depth measured in vivo at the age of 118.1±1.16?dBF2, Backfat depth measured in vivo at the age of 145.9±1.53?dBF3, Backfat depth measured in vivo at the age of 174.3±1.43?dBF4, Backfat depth measured in vivo at the age of 196.6±8.03?dBFt, Backfat measured post mortem (after slaughter at 196.6±8.03?d)Causal effectFATg, Latent variable built on BF1, BF2, and BF3FATt, Latent variable built on BF4, BFt, and BELFat depositionG, host genomic features, represented in this study by SNPGut microbiomeLatent variablesM, gut microbiome features, represented in this study by OUTMod1, Model 1, used to estimate the total effect of G on P. Reported in Fig. 1aMod1L, Model 1L, used to estimate the total effect of G onMod2, Model 2, used to estimate the effect of M on P. Reported in Fig. 1bMod2L, Model 2L, used to estimate the effect of M onMod3, Model 3, used to estimate the effect of G on M. Reported in Fig. S1Mod4, Model 4, used to estimate the direct and mediated effects of G on P. Reported in Fig. 1cMod4L, Model 4, used to estimate the direct and mediated effects of G on. Reported in Fig. 1dOUT, Operational Taxonomic UnitsP, Phenotype recorded on the hostS2a, S2b, S3a, S3b, S3c, Gut microbiome OUT selected used as mediator variables. See Table 2SEM, Structural equation modelSNP, Single Nucleotide Polymorphism markerΠ, Latent variable built on the P variables
DOI
10.1016/j.csbj.2020.12.038
PMID
33510859
发布时间
2021-01-30
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