H3K27me3-rich genomic regions can function as silencers to repress gene expression via chromatin interactions.

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作者： Yichao,Cai ^[1] ; Ying,Zhang ^[2] ; Yan Ping,Loh ^[1] ; Jia Qi,Tng ^[1] ; Mei Chee,Lim ^[1] ; Zhendong,Cao ^[1] ; Anandhkumar,Raju ^[3] ; Erez,Lieberman Aiden ^[1] ; Shang,Li ^[4] ; Lakshmanan,Manikandan ^[5] ; Vinay,Tergaonkar ^[6] ; Greg,Tucker-Kellogg ^[3] ; Melissa Jane,Fullwood ^[7]

作者单位： Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. ^[1] Department of Biological Sciences, National University of Singapore, Singapore, Singapore. ^[2] Cancer and Stem Cell Biology Programme, Duke-NUS Medical School, Singapore, Singapore. ^[3] Department of Cancer Biology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA. ^[4] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore. ^[5] Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA. ^[6] Department of Physiology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore. ^[7] Department of Biological Sciences, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg. ^[8] Computational Biology Programme, National University of Singapore, Singapore, Singapore. dbsgtk@nus.edu.sg. ^[9] Cancer Science Institute of Singapore, National University of Singapore, Singapore, Singapore. mfullwood@ntu.edu.sg. ^[10] Institute of Molecular and Cell Biology, Agency for Science, Technology and Research (A*STAR), Proteos, Singapore. mfullwood@ntu.edu.sg. ^[11] School of Biological Sciences, Nanyang Technological University, Singapore, Singapore. mfullwood@ntu.edu.sg. ^[12]