Spatial N-glycomics of the human aortic valve in development and pediatric endstage congenital aortic valve stenosis.

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作者： Peggi M,Angel ^[1] ; Richard R,Drake ^[2] ; Yeonhee,Park ^[3] ; Cassandra L,Clift ^[2] ; Connor,West ^[2] ; Savanna,Berkhiser ^[2] ; Gary,Hardiman ^[4] ; Anand S,Mehta ^[2] ; David P,Bichell ^[5] ; Yan Ru,Su ^[6]

作者单位： Department of Cell and Molecular Pharmacology & Experimental Therapeutics; MUSC Proteomics Group; Bruker Clinial Glycomics Center of Excellence, Medical University of South Carolina, Charleston, SC, United States of America. Electronic address: angelp@musc.edu. ^[1] Department of Cell and Molecular Pharmacology & Experimental Therapeutics; MUSC Proteomics Group; Bruker Clinial Glycomics Center of Excellence, Medical University of South Carolina, Charleston, SC, United States of America. ^[2] University of Wisconsin-Madison, Department of Biostatistics and Medical Informatics, Madison, WI, United States of America. ^[3] School of Biological Sciences, Queen's University, Belfast, United Kingdom. ^[4] Division of Pediatric Cardiac Surgery, Vanderbilt University Medical Center, Nashville, TN, United States of America. ^[5] Division of Cardiovascular Medicine, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, United States of America. ^[6]

关键词 Aortic valve Congenital aortic valve stenosis Extracellular matrix Imaging mass spectrometry MALDI imaging mass spectrometry N-glycan N-glycosylation Tissue imaging Valve development