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Increased APOE ε4 expression is associated with the difference in Alzheimer's disease risk from diverse ancestral backgrounds.

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第一作者： Anthony J,Griswold

第一单位： John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA.;Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA.

作者： Anthony J,Griswold ^[1] ; Katrina,Celis ^[2] ; Parker L,Bussies ^[2] ; Farid,Rajabli ^[2] ; Patrice L,Whitehead ^[2] ; Kara L,Hamilton-Nelson ^[2] ; Gary W,Beecham ^[1] ; Derek M,Dykxhoorn ^[1] ; Karen,Nuytemans ^[1] ; Liyong,Wang ^[1] ; Olivia K,Gardner ^[2] ; Daniel A,Dorfsman ^[2] ; Eileen H,Bigio ^[3] ; Marek Marsel,Mesulam ^[3] ; Sandra,Weintraub ^[3] ; Changiz,Geula ^[3] ; Marla,Gearing ^[4] ; Elisa,McGrath-Martinez ^[5] ; Clifton L,Dalgard ^[6] ; William K,Scott ^[1] ; Jonathan L,Haines ^[7] ; Margaret A,Pericak-Vance ^[1] ; Juan I,Young ^[1] ; Jeffery M,Vance ^[1]

作者单位： John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA.;Dr. John T Macdonald Foundation Department of Human Genetics, University of Miami Miller School of Medicine, Miami, Florida, USA. ^[1] John P. Hussman Institute for Human Genomics, Miller School of Medicine, University of Miami, Miami, Florida, USA. ^[2] Northwestern ADC Neuropathology Core, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA. ^[3] Goizueta Alzheimer's Disease Research Center, Emory University, Atlanta, Georgia, USA. ^[4] The American Genome Center, Uniformed Services University, Bethesda, Maryland, USA.;Collaborative Health Initiative Research Program, Henry Jackson Foundation, Bethesda, Maryland, USA. ^[5] Collaborative Health Initiative Research Program, Henry Jackson Foundation, Bethesda, Maryland, USA.;Department of Anatomy Physiology & Genetics, Uniformed Services University, Bethesda, Maryland, USA. ^[6] Cleveland Institute for Computational Biology, Case Western Reserve University, Cleveland, Ohio, USA. ^[7]

关键词 APOE Alzheimer's disease local ancestry single-nucleus RNA-seq