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Optimization of Benzothiazole and Thiazole Hydrazones as Inhibitors of Schistosome BCL-2.

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第一作者： William,Nguyen

第一单位： The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.;Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.

作者： William,Nguyen ^[1] ; Erinna F,Lee ^[2] ; Marco,Evangelista ^[3] ; Mihwa,Lee ^[4] ; Tiffany J,Harris ^[3] ; Peter M,Colman ^[1] ; Nicholas A,Smith ^[4] ; Luke B,Williams ^[5] ; Kate E,Jarman ^[1] ; Kym N,Lowes ^[1] ; Cécile,Haeberli ^[6] ; Jennifer,Keiser ^[6] ; Brian J,Smith ^[4] ; W Douglas,Fairlie ^[2] ; Brad E,Sleebs ^[7]

作者单位： The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.;Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia. ^[1] La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Australia.;Olivia Newton-John Cancer Research Institute, Heidelberg 3084, Australia.;School of Cancer Medicine, La Trobe University, Melbourne 3086, Australia. ^[2] Olivia Newton-John Cancer Research Institute, Heidelberg 3084, Australia. ^[3] La Trobe Institute for Molecular Science, La Trobe University, Melbourne 3086, Australia. ^[4] The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia. ^[5] Department of Medical Parasitology and Infection Biology, Swiss Tropical and Public Health Institute, Basel 4002, Switzerland.;University of Basel, Basel 4001, Switzerland. ^[6] The Walter and Eliza Hall Institute of Medical Research, Parkville 3052, Australia.;Department of Medical Biology, The University of Melbourne, Parkville 3010, Australia.;Department of Veterinary Biosciences, The University of Melbourne, Parkville 3010, Australia. ^[7]

关键词 BCL-2 BCL-XL BH3-mimetic benzothiazole schistosomiasis

医学主题词动物(Animals);细胞凋亡(Apoptosis);苯并噻唑类(Benzothiazoles);人类(Humans);腙类(Hydrazones);血吸虫属(Schistosoma);bcl-X蛋白质(bcl-X Protein)

DOI 10.1021/acsinfecdis.0c00700

PMID 33523649

发布时间 2021-06-23

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