New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

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第一作者： Martina,Durcik

第一单位： University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia.

作者： Martina,Durcik ^[1] ; Ákos,Nyerges ^[2] ; Žiga,Skok ^[1] ; Darja Gramec,Skledar ^[1] ; Jurij,Trontelj ^[1] ; Nace,Zidar ^[1] ; Janez,Ilaš ^[1] ; Anamarija,Zega ^[1] ; Cristina D,Cruz ^[3] ; Päivi,Tammela ^[3] ; Martin,Welin ^[4] ; Yengo R,Kimbung ^[4] ; Dorota,Focht ^[4] ; Ondřej,Benek ^[5] ; Tamás,Révész ^[2] ; Gábor,Draskovits ^[2] ; Petra Éva,Szili ^[2] ; Lejla,Daruka ^[2] ; Csaba,Pál ^[2] ; Danijel,Kikelj ^[1] ; Lucija Peterlin,Mašič ^[6] ; Tihomir,Tomašič ^[7]

作者单位： University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. ^[1] Synthetic and Systems Biology Unit, Institute of Biochemistry, Biological Research Centre, Szeged, H-6726, Hungary. ^[2] Drug Research Program, Division of Pharmaceutical Biosciences, Faculty of Pharmacy, University of Helsinki, P.O. Box 56 (Viikinkaari 5 E), 00014, Helsinki, Finland. ^[3] SARomics Biostructures, Medicon Village, Lund, Sweden. ^[4] University of Hradec Kralove, Faculty of Science, Department of Chemistry, Rokitanskeho 62, 500 03, Hradec Kralove, Czech Republic. ^[5] University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. Electronic address: Lucija.PeterlinMasic@ffa.uni-lj.si. ^[6] University of Ljubljana, Faculty of Pharmacy, Aškerčeva cesta 7, 1000, Ljubljana, Slovenia. Electronic address: Tihomir.Tomasic@ffa.uni-lj.si. ^[7]

关键词 Antibacterial Benzothiazole DNA gyrase Dual inhibitor Topoisomerase IV