Chloroquine and Hydroxychloroquine Interact Differently with ACE2 Domains Reported to Bind with the Coronavirus Spike Protein: Mediation by ACE2 Polymorphism.

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作者： Riadh,Badraoui ^[1] ; Mohd,Adnan ^[2] ; Fevzi,Bardakci ^[3] ; Mousa M,Alreshidi ^[1]

作者单位： Laboratory of General Biology, Department of Biology, University of Ha'il, Ha'il 81451, Saudi Arabia. ^[1] Section of Histology-Cytology, Medicine College of Tunis, University of Tunis El Manar, Djebel Lakhdhar Road, La Rabta-Tunis 1007, Tunisia. ^[2] Laboratory of Histo-Embryology and Cytogenetic, Medicine College of Sfax, University of Sfax, Majida Boulila Road, Sfax 3029, Tunisia. ^[3] Laboratory of Genetics, Department of Biology, Aydin Adnan Menderes University, Aydin 09010, Turkey. ^[4] Molecular Diagnostic and Personalized Therapeutics Unit, University of Ha'il, Ha'il 81451, Saudi Arabia. ^[5]

关键词 ACE2 allelic variants binding domain chloroquine coronavirus hydroxychloroquine in silico molecular docking molecular interactions

主题词氯喹(Chloroquine);人类(Humans);羟氯喹(Hydroxychloroquine);多态现象, 遗传(Polymorphism, Genetic)

DOI 10.3390/molecules26030673

PMID 33525415

发布时间 2022-12-07

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