首页> EBioMedicine> A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).

A chemical genetic screen identifies Aurora kinases as a therapeutic target in EGFR T790M negative, gefitinib-resistant head and neck squamous cell carcinoma (HNSCC).

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第一作者： Joo-Leng,Low

第一单位： Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore.

作者： Joo-Leng,Low ^[1] ; Dawn Pingxi,Lau ^[2] ; Xiaoqian,Zhang ^[1] ; Xue-Lin,Kwang ^[2] ; Neha,Rohatgi ^[3] ; Jane Vin,Chan ^[4] ; Fui-Teen,Chong ^[2] ; Stephen Qi Rong,Wong ^[1] ; Hui-Sun,Leong ^[2] ; Matan Thangavelu,Thangavelu ^[5] ; Shivaji,Rikka ^[6] ; Anders Martin Jacobsen,Skanderup ^[3] ; Daniel Shao Weng,Tan ^[2] ; Giridharan,Periyasamy ^[5] ; Judice Lie Yong,Koh ^[4] ; N Gopalakrishna,Iyer ^[7] ; Ramanuj,DasGupta ^[8]

作者单位： Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore. ^[1] Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore 169610, Singapore. ^[2] Laboratory of Computational Cancer Genomics, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore. ^[3] Computational Phenomics Platform, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore. ^[4] Centre for High Throughput Phenomics (CHiP-GIS), Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore. ^[5] Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore; Centre for High Throughput Phenomics (CHiP-GIS), Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), Singapore. ^[6] Cancer Therapeutics Research Laboratory, National Cancer Centre Singapore, 11 Hospital Crescent, Singapore 169610, Singapore. Electronic address: gopaliyer@singhealth.com.sg. ^[7] Laboratory of Precision Oncology and Cancer Evolution, Genome Institute of Singapore, Agency for Science, Technology and Research (A*STAR), 60 Biopolis Street, Genome #02-01, Singapore 138672, Singapore. Electronic address: dasguptar@gis.a-star.edu.sg. ^[8]

关键词 Aurora kinase inhibition Chemical genetics EGFR T790M negative Gefitinib resistance Head and neck squamous cell carcinoma