SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation.

导出 LinkOut

翻译打印收藏纠错

作者： Yanying,Zhou ^[1] ; Xiaomei,Fan ^[2] ; Tingying,Jiao ^[1] ; Wenzhou,Li ^[2] ; Panpan,Chen ^[1] ; Yiming,Jiang ^[1] ; Jiahong,Sun ^[1] ; Yixin,Chen ^[1] ; Pan,Chen ^[3] ; Lihuan,Guan ^[1] ; Yajie,Wen ^[1] ; Min,Huang ^[1] ; Huichang,Bi ^[1]

作者单位： School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China. ^[1] Shenzhen Baoan Women's and Children's Hospital, Jinan University, Shenzhen 518102, China. ^[2] Department of Pharmacy, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. ^[3]

关键词 AAV, adeno-associated virus ALF, acute liver failure ALT, serum alanine aminotransferase APAP, acetaminophen ARE, antioxidant response element AST, aspartate aminotransferase Acetaminophen BCA, bicinchoninic acid BrdU, bromodeoxyuridine CCK-8, cell counting kit-8 CCNA1, cyclin A1 CCND1, cyclin D1 CDK4, cyclin-dependent kinase 4 CYP450, cytochromes P450 Co-IP, co-immunoprecipitation DCF, dichlorofluorescein Dox, doxorubicin ECL, electrochemiluminescence GSH, glutathione GSTα, glutathianone S-transferase α GSTμ, glutathione S-transferase μ H&E, hematoxylin and eosin H3K56ac, histone H3 Nε-acetyl-lysines 56 H3K9ac, histone H3 Nε-acetyl-lysines 9 HO-1, heme oxygenase-1 Hepatotoxicity KEAP1, Kelch-like ECH-associated protein 1 LDH, lactate dehydrogenase NAPQI, N-acetyl p-benzoquinone imine NQO1, NAD(P)H quinone dehydrogenase 1 NRF2 NRF2, nuclear factor erythroid 2-related factor 2 P53 ROS, reactive oxygen species SIRT6 SIRT6, sirtuin 6 siRNA, small interfering RNA

DOI 10.1016/j.apsb.2020.06.016

PMID 33532182

发布时间 2021-02-06

翻译满意度评价：

准确一般字义偏差语意偏离译文作用小提交

浏览0

Acta pharmaceutica Sinica. B

2021年11卷1期

89-99页

相似文献

中文期刊
外文期刊
学位论文
会议论文

检索历史清除

SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation.

Acta pharmaceutica Sinica. B

相似文献

Acta pharmaceutica Sinica. B

相关期刊

参考文献：
指定格式：	NoteExpress EndNote RefWorks NoteFirst

检索历史 清除

SIRT6 as a key event linking P53 and NRF2 counteracts APAP-induced hepatotoxicity through inhibiting oxidative stress and promoting hepatocyte proliferation.

Acta pharmaceutica Sinica. B

相似文献

Acta pharmaceutica Sinica. B

相关期刊

检索历史清除