VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses.

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第一作者： Yilan,Shen

第一单位： Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China.

作者： Yilan,Shen ^[1] ; Wei,Chen ^[2] ; Lei,Han ^[3] ; Qi,Bian ^[1] ; Jiajun,Fan ^[3] ; Zhonglian,Cao ^[3] ; Xin,Jin ^[3] ; Tao,Ding ^[1] ; Zongshu,Xian ^[3] ; Zhiyong,Guo ^[1] ; Wei,Zhang ^[4] ; Dianwen,Ju ^[3] ; Xiaobin,Mei ^[1]

作者单位： Department of Nephrology, Changhai Hospital, Second Military Medical University, Shanghai 200433, China. ^[1] Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China.;Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, CA 94304, USA. ^[2] Department of Biological Medicines, Fudan University School of Pharmacy, Shanghai 201203, China. ^[3] Department of Nephrology, Shanghai Yangpu Hospital of TCM, Shanghai 200090, China. ^[4]

关键词 ACR, urine albumin-to-creatinine ratio ADFP, adipocyte differentiation-related protein AGEs, advanced glycation end products ALT, alanine aminotransferase AST, aspartate aminotransferase BUN, blood urea nitrogen Ccr, creatinine clearance rate DN, diabetic nephropathy Diabetic nephropathy ECM, extracellular matrix ESRD, end-stage renal disease FA, fatty acid FATPs, fatty acid transport proteins Fusion protein GBM, glomerular basement membrane GSEA, gene set enrichment analysis H&E, hematoxylin & eosin HbA1c , glycosylated hemoglobin IL-22, interleukin-22 Interleukin-22 KEGG, Kyoto Encyclopedia of Genes and Genomes NAC, N-acetyl-l-cysteine NLRP3, NOD-like receptor family pyrin domain-containing protein 3 NRP-1, neuropilin-1 PAS, periodic acid-Schiff ROS, reactive oxygen species SDS-PAGE, SDS-polyacrylamide gel electrophoresis TEM, transmission electron microscopy VEGF-B, vascular endothelial growth factor B VEGFR, vascular endothelial growth factor receptor Vascular endothelial growth factor B eGFR, estimated glomerular filtration rate β2-MG, β2 microglobulin

DOI 10.1016/j.apsb.2020.07.002

PMID 33532185

发布时间 2021-02-06

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Acta pharmaceutica Sinica. B

2021年11卷1期

127-142页

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VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses.

Acta pharmaceutica Sinica. B

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Acta pharmaceutica Sinica. B

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VEGF-B antibody and interleukin-22 fusion protein ameliorates diabetic nephropathy through inhibiting lipid accumulation and inflammatory responses.

Acta pharmaceutica Sinica. B

相似文献

Acta pharmaceutica Sinica. B

相关期刊

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