首页> Biochemical pharmacology> His452Tyr polymorphism in the human 5-HT<sub>2A</sub> receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.

His452Tyr polymorphism in the human 5-HT<sub>2A</sub> receptor affects clozapine-induced signaling networks revealed by quantitative phosphoproteomics.

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第一作者： Sandra M,Martín-Guerrero

第一单位： Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Granada. Spain.

作者： Sandra M,Martín-Guerrero ^[1] ; Paula,Alonso ^[2] ; Alba,Iglesias ^[2] ; Marta,Cimadevila ^[2] ; José,Brea ^[2] ; M Isabel,Loza ^[2] ; Pedro,Casado ^[3] ; David,Martín-Oliva ^[1] ; Pedro R,Cutillas ^[3] ; Javier,González-Maeso ^[4] ; Juan F,López-Giménez ^[5]

作者单位： Departamento de Biología Celular, Facultad de Ciencias, Universidad de Granada, Granada. Spain. ^[1] Biofarma Research Group, Depto Farmacoloxía, Farmacia e Tecnoloxía Farmacéutica, Facultad de Farmacia, Centro de investigación CIMUS, Universidad de Santiago de Compostela, Santiago de Compostela. Spain. ^[2] Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, Charterhouse Square, London EC1M 6BQ, UK. ^[3] Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA. Electronic address: javier.maeso@vcuhealth.org. ^[4] Department of Physiology and Biophysics, Virginia Commonwealth University School of Medicine, Richmond, VA 23298, USA; Instituto de Parasitología y Biomedicina "López-Neyra", CSIC, E-18016 Granada, Spain. Electronic address: jf.lopez.gimenez@csic.es. ^[5]

关键词 5-HT(2A) receptor Antipsychotics Clozapine G protein-coupled receptor (GPCR)Phosphoproteomics Polymorphism Schizophrenia