Sulthiame impairs mitochondrial function in vitro and may trigger onset of visual loss in Leber hereditary optic neuropathy.

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作者： Marie-Christine,Reinert ^[1] ; David,Pacheu-Grau ^[2] ; Claudia B,Catarino ^[3] ; Thomas,Klopstock ^[3] ; Andreas,Ohlenbusch ^[4] ; Michael,Schittkowski ^[5] ; Ekkehard,Wilichowski ^[6] ; Peter,Rehling ^[7] ; Knut,Brockmann ^[6]

作者单位： Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. marie-christine.reinert@med.uni-goettingen.de. ^[1] Department of Cellular Biochemistry, University Medical Center Göttingen, Göttingen, Germany. ^[2] Department of Neurology, Friedrich-Baur-Institute, University Hospital, LMU Munich, Munich, Germany. ^[3] German Center for Neurodegenerative Diseases (DZNE), Munich, Germany. ^[4] Munich Cluster for Systems Neurology (SyNergy), Munich, Germany. ^[5] Division of Pediatric Neurology, Department of Pediatrics and Adolescent Medicine, University Medical Center Göttingen, Robert-Koch-Str. 40, 37075, Göttingen, Germany. ^[6] Department of Ophthalmology, Section for Strabismus, Neuroophthalmology and Oculoplastics, University Medical Center Göttingen, Göttingen, Germany. ^[7] Cluster of Excellence "Multiscale Bioimaging: From Molecular Machines To Networks of Excitable Cells" (MBExC), University of Göttingen, Göttingen, Germany. ^[8] Max Planck Institute for Biophysical Chemistry, Göttingen, Germany. ^[9] Interdisciplinary Pediatric Center for Children With Developmental Disabilities and Severe Chronic Disorders, University Medical Center Göttingen, Göttingen, Germany. ^[10]

关键词 Adverse effects Carbonic anhydrase inhibitor LHON Leber hereditary optic neuropathy Oxygen consumption rate Sulthiame