Biphasic Activation of WNT Signaling Facilitates the Derivation of Midbrain Dopamine Neurons from hESCs for Translational Use.

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作者： Tae Wan,Kim ^[1] ; Jinghua,Piao ^[2] ; So Yeon,Koo ^[3] ; Sonja,Kriks ^[4] ; Sun Young,Chung ^[1] ; Doron,Betel ^[5] ; Nicholas D,Socci ^[6] ; Se Joon,Choi ^[7] ; Susan,Zabierowski ^[8] ; Brittany N,Dubose ^[8] ; Ellen J,Hill ^[8] ; Eugene V,Mosharov ^[7] ; Stefan,Irion ^[1] ; Mark J,Tomishima ^[8] ; Viviane,Tabar ^[9] ; Lorenz,Studer ^[10]

作者单位： Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[1] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Neurosurgery and Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[2] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Neuroscience Graduate Program of Weill Cornell Graduate School of Biomedical Sciences, Weill Cornell Medical College, New York, NY, USA. ^[3] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[4] Institute for Computational Biomedicine, Division of Hematology/Oncology, Department of Medicine, Weill Cornell Medical College, New York, NY, USA. ^[5] Bioinformatics Core, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[6] Department of Neurology, Columbia University Medical Center, New York, NY, USA. ^[7] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; SKI Stem Cell Research Facility, Memorial Sloan Kettering Cancer Center, New York, NY, USA. ^[8] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Department of Neurosurgery and Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Cancer Biology & Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: tabarv@mskcc.org. ^[9] Center for Stem Cell Biology, Memorial Sloan Kettering Cancer Center, New York, NY, USA; Developmental Biology Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA. Electronic address: studerl@mskcc.org. ^[10]

关键词 Parkinson’s disease WNT signaling cell therapy directed differentiation human embryonic stem cells human-induced pluripotent stem cells midbrain development neural patterning preclinical study transplantation

主题词动物(Animals);细胞分化(Cell Differentiation);中脑(Mesencephalon);大鼠(Rats)

DOI 10.1016/j.stem.2021.01.005

PMID 33545081

发布时间 2022-02-05

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