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Sorted B cell transcriptomes point towards actively regulated B cell responses during ongoing chronic hepatitis B infections.

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第一作者： Stijn,Van Hees

第一单位： Department of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Antwerp, Belgium; Laboratory of Experimental Medicine and Paediatrics, Antwerp University, Universiteitsplein 1, 2610 Antwerp, Belgium.

作者： Stijn,Van Hees ^[1] ; Bart,Cuypers ^[2] ; Stefan,Bourgeois ^[3] ; Zwier M A,Groothuismink ^[4] ; Pieter,Meysman ^[5] ; Pieter,Van der Vlies ^[6] ; Rob,de Knegt ^[4] ; Luisa,Vonghia ^[1] ; Peter,Michielsen ^[1] ; Sven,Francque ^[1] ; Kris,Laukens ^[5] ; Andre,Boonstra ^[4] ; Thomas,Vanwolleghem ^[7]

作者单位： Department of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Antwerp, Belgium; Laboratory of Experimental Medicine and Paediatrics, Antwerp University, Universiteitsplein 1, 2610 Antwerp, Belgium. ^[1] Department of Biomedical Sciences, Institute of Tropical Medicine, Kronenburgstraat 43, 2000 Antwerp, Belgium; Department of Mathematics and Computer Science, University of Antwerp, Middelheimlaan 1, 2020 Antwerp, Belgium. ^[2] Department of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Antwerp, Belgium; Department of Gastroenterology and Hepatology, ZNA Stuivenberg, Antwerp, Belgium. ^[3] Department of Gastroenterology and Hepatology, Erasmus Medical Center Rotterdam, the Netherlands. ^[4] Department of Mathematics and Computer Science, University of Antwerp, Middelheimlaan 1, 2020 Antwerp, Belgium. ^[5] Department of Genetics, University Medical Center Groningen, the Netherlands. ^[6] Department of Gastroenterology and Hepatology, Antwerp University Hospital, Wilrijkstraat 10, 2650 Antwerp, Belgium; Laboratory of Experimental Medicine and Paediatrics, Antwerp University, Universiteitsplein 1, 2610 Antwerp, Belgium; Department of Gastroenterology and Hepatology, Erasmus Medical Center Rotterdam, the Netherlands. Electronic address: Thomas.vanwolleghem@uza.be. ^[7]

关键词 Activation B cells HBeAg seroconversion Hepatitis B Intrahepatic RNA sequencing