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首页> Molecular autism> Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.

Mind the translational gap: using iPS cell models to bridge from genetic discoveries to perturbed pathways and therapeutic targets.

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作者： Greta,Pintacuda ^[1] ; Jacqueline M,Martín ^[2] ; Kevin C,Eggan ^[3]

作者单位： Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. gretapintacuda@fas.harvard.edu. ^[1] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. gretapintacuda@fas.harvard.edu. ^[2] Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. ^[3] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. ^[4] Department of Stem Cell and Regenerative Biology, Department of Molecular and Cellular Biology, Harvard Stem Cell Institute, Cambridge, MA, 02138, USA. eggan@mcb.harvard.edu. ^[5] Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, 02142, USA. eggan@mcb.harvard.edu. ^[6]

关键词 Differentiation NPC Neurodevelopment Neurons iPSC (induced-pluripotent stem cells)

主题词细胞培养技术(Cell Culture Techniques);遗传关联研究(Genetic Association Studies);疾病遗传易感性(Genetic Predisposition to Disease);人类(Humans);诱导多能干细胞(Induced Pluripotent Stem Cells);分子靶向治疗(Molecular Targeted Therapy);多因子遗传(Multifactorial Inheritance);表型(Phenotype)

DOI 10.1186/s13229-021-00417-x

PMID 33557935

发布时间 2023-11-10

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Molecular autism

Molecular autism

2021年12卷1期

10页

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