Experiments and simulation on ZIKV NS2B-NS3 protease reveal its complex folding.

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作者： Ankur,Kumar ^[1] ; Prateek,Kumar ^[1] ; Murali,Aarthy ^[2] ; Sanjeev Kumar,Singh ^[2] ; Rajanish,Giri ^[3]

作者单位： School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, 175005, Himachal Pradesh, India. ^[1] Department of Bioinformatics, Computer Aided Drug Design and Molecular Modeling Laboratory, Alagappa University, Science Block, Karaikudi, 630003, Tamil Nadu, India. ^[2] School of Basic Sciences, Indian Institute of Technology Mandi, Mandi, 175005, Himachal Pradesh, India. Electronic address: rajanishgiri@gmail.com. ^[3]

关键词 Conformational transition Equilibrium unfolding NS2B-NS3 protease Structural stability Thermal denaturation Zika virus

主题词氢离子浓度(Hydrogen-Ion Concentration);蛋白质结合(Protein Binding);蛋白质折叠(Protein Folding);蛋白质结构, 二级(Protein Structure, Secondary);丝氨酸内肽酶类(Serine Endopeptidases);病毒非结构蛋白质类(Viral Nonstructural Proteins);病毒蛋白质类(Viral Proteins)

DOI 10.1016/j.virol.2021.01.014

PMID 33561698

发布时间 2021-12-29

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