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New Quinoxaline Derivatives as Dual Pim-1/2 Kinase Inhibitors: Design, Synthesis and Biological Evaluation.

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第一作者： Bruno,Oyallon

第一单位： EA GICC-ERL 7001 CNRS, Team IMT, University of Tours, F-37200 Tours, France.

作者： Bruno,Oyallon ^[1] ; Marie,Brachet-Botineau ^[2] ; Cédric,Logé ^[3] ; Thomas,Robert ^[4] ; Stéphane,Bach ^[5] ; Sajida,Ibrahim ^[6] ; William,Raoul ^[7] ; Cécile,Croix ^[1] ; Pascal,Berthelot ^[8] ; Jean,Guillon ^[9] ; Noël,Pinaud ^[10] ; Fabrice,Gouilleux ^[2] ; Marie-Claude,Viaud-Massuard ^[1] ; Caroline,Denevault-Sabourin ^[1]

作者单位： EA GICC-ERL 7001 CNRS, Team IMT, University of Tours, F-37200 Tours, France. ^[1] CNRS ERL7001 LNOx-EA GICC, University of Tours, F-37000 Tours, France. ^[2] Department of Medicinal Chemistry, IICIMED-EA1155, IRS2, University of Nantes, F-44200 Nantes, France. ^[3] Integrative Biology of Marine Models Laboratory (LBI2M), Sorbonne University, CNRS, UMR8227, F-29680 Roscoff, France.;Kinase Inhibitor Specialized Screening facility (KISSf), Sorbonne University, CNRS, FR2424, F-29680 Roscoff, France. ^[4] Integrative Biology of Marine Models Laboratory (LBI2M), Sorbonne University, CNRS, UMR8227, F-29680 Roscoff, France.;Kinase Inhibitor Specialized Screening facility (KISSf), Sorbonne University, CNRS, FR2424, F-29680 Roscoff, France.;Centre of Excellence for Pharmaceutical Sciences, North-West University, Private Bag X6001, Potchefstroom 2520, South Africa. ^[5] EA GICC-ERL 7001 CNRS, Team PATCH, University of Tours, F-37200 Tours, France. ^[6] EA GICC-ERL 7001 CNRS, Team PATCH, University of Tours, F-37200 Tours, France.;N2C, University of Tours, INSERM, UMR 1069, F-37032 Tours, France. ^[7] UMR-S 1172-JPArc, University of Lille, INSERM, CHU Lille, F-59000 Lille, France. ^[8] ARNA Laboratory, University of Bordeaux, INSERM U12132-UMR CNRS 5320, F-33076 Bordeaux, France. ^[9] ISM, University of Bordeaux, CNRS, UMR 5255, F-33405 Talence, France. ^[10]

关键词 Pim kinases anticancer targeted therapy kinase inhibitor quinoxaline

医学主题词人类(Humans);蛋白质构象(Protein Conformation);蛋白激酶抑制剂(Protein Kinase Inhibitors);原癌基因蛋白质类(Proto-Oncogene Proteins);原癌基因蛋白质c-pim-1(Proto-Oncogene Proteins c-pim-1);喹恶啉类(Quinoxalines)

DOI 10.3390/molecules26040867

PMID 33562106

发布时间 2021-12-04

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