Genetically determined blood pressure, antihypertensive medications, and risk of Alzheimer's disease: a Mendelian randomization study.

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作者： Ya-Nan,Ou ^[1] ; Yu-Xiang,Yang ^[2] ; Xue-Ning,Shen ^[2] ; Ya-Hui,Ma ^[1] ; Shi-Dong,Chen ^[2] ; Qiang,Dong ^[3] ; Lan,Tan ^[4] ; Jin-Tai,Yu ^[5]

作者单位： Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China. ^[1] Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. ^[2] Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. dong_qiang@fudan.edu.cn. ^[3] Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, 266071, China. dr.tanlan@163.com. ^[4] Department of Neurology and Institute of Neurology, WHO Collaborating Center for Research and Training in Neurosciences, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China. jintai_yu@fudan.edu.cn. ^[5]

关键词 Alzheimer’s disease Antihypertensive medications Blood pressure Mendelian randomization Single nucleotide polymorphism

主题词阿尔茨海默病(Alzheimer Disease);抗高血压药(Antihypertensive Agents);血压(Blood Pressure);全基因组关联研究(Genome-Wide Association Study);人类(Humans);孟德尔随机化分析(Mendelian Randomization Analysis);多态性, 单核苷酸(Polymorphism, Single Nucleotide)

DOI 10.1186/s13195-021-00782-y

PMID 33563324

发布时间 2024-04-01

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