A first-in-human study of <sup>11</sup>C-MTP38, a novel PET ligand for phosphodiesterase 7.

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第一作者： Manabu,Kubota

第一单位： Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. kubota.manabu@qst.go.jp.;Department of Psychiatry, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan. kubota.manabu@qst.go.jp.

作者： Manabu,Kubota ^[1] ; Chie,Seki ^[2] ; Yasuyuki,Kimura ^[3] ; Keisuke,Takahata ^[4] ; Hitoshi,Shimada ^[2] ; Yuhei,Takado ^[2] ; Kiwamu,Matsuoka ^[2] ; Kenji,Tagai ^[5] ; Yasunori,Sano ^[4] ; Yasuharu,Yamamoto ^[4] ; Maki,Okada ^[6] ; Tatsuya,Kikuchi ^[6] ; Masanori,Ichise ^[3] ; Kazunori,Kawamura ^[6] ; Ming-Rong,Zhang ^[6] ; Makoto,Higuchi ^[2]

作者单位： Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. kubota.manabu@qst.go.jp.;Department of Psychiatry, Kyoto University Graduate School of Medicine, 54 Shogoin Kawahara-cho, Sakyo-ku, Kyoto, Japan. kubota.manabu@qst.go.jp. ^[1] Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan. ^[2] Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, 7-430 Morioka, Obu, Aichi, Japan. ^[3] Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Neuropsychiatry, Keio University School of Medicine, 35 Shinanomachi, Shinjuku, Tokyo, Japan. ^[4] Department of Functional Brain Imaging, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage-ku, Chiba, Chiba, 263-8555, Japan.;Department of Psychiatry, The Jikei University Graduate School of Medicine, Tokyo, 105-8461, Japan. ^[5] Department of Radiopharmaceuticals Development, National Institute of Radiological Sciences, National Institutes for Quantum and Radiological Science and Technology, 4-9-1 Anagawa, Inage, Chiba, Chiba, Japan. ^[6]

关键词 11C-MTP38 PDE7 Positron emission tomography Quantification